Brief Information of the Cell Line and Protein
Cell Line ID: CL000155 , HT-144
 Cell Line Info 
Synonyms
HT 144
HT144
HT144-mel
HT144mel
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0318
Protein ID: PT00955 , DNA-dependent protein kinase catalytic subunit
 Protein Info 
Gene Name PRKDC
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P78527
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000155
 Cell Line Info 
 Protein ID: PT00955
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0014320
 Compound Info 
CHEMBL4871998
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C21H17F2N5
  1
1
IC50 = 44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014706
 Compound Info 
8-[5-(difluoromethyl)pyridin-3-yl]-1-(3,6-dihydro-2H-pyran-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C20H15F2N5O
  1
1
IC50 = 47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0013686
 Compound Info 
8-[5-(difluoromethyl)pyridin-3-yl]-1-(4-methoxycyclohexyl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H21F2N5O
  1
1
IC50 = 53 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014718
 Compound Info 
1-(cyclohepten-1-yl)-8-[5-(difluoromethyl)pyridin-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H19F2N5
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0013685
 Compound Info 
8-[5-(difluoromethyl)pyridin-3-yl]-1-(2,3,6,7-tetrahydrooxepin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C21H17F2N5O
  1
1
IC50 = 69 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003520
 Compound Info 
8-[5-(difluoromethyl)pyridin-3-yl]-1-(4-methoxycyclohexyl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C22H21F2N5O
  1
1
IC50 = 92 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0005823
 Compound Info 
CHEMBL4873263
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C20H15F2N5O
  1
1
IC50 = 98 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014710
 Compound Info 
1-(cyclohexen-1-yl)-8-[5-(difluoromethyl)pyridin-3-yl]-[1,2,4]triazolo[4,3-a]quinoxaline
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C21H17F2N5
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014701
 Compound Info 
8-[5-(difluoromethyl)pyridin-3-yl]-1-(oxan-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline
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C20H17F2N5O
  1
1
IC50 = 1130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS