Brief Information of the Cell Line and Protein
Cell Line ID: CL000760 , PAE
Synonyms
pig aortic endothelial
Category Transformed cell line
Organism
Sus scrofa (Pig)
Cellosaurus ID
CVCL_RX28
Protein ID: PT00934 , High affinity nerve growth factor receptor
Gene Name NTRK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P04629
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000760  Protein ID: PT00934
 
Compound ID Compound Name Compound Formula
CP0186372
5-(carbamoylamino)-3-[(5R)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylsulfanyl]-1,2-thiazole-4-carboxamide
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C16H18N4O2S2
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0186373
5-(carbamoylamino)-3-{6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylsulfanyl}-1,2-thiazole-4-carboxamide
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C16H18N4O2S2
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0285447
3-{[(1R)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C15H17ClN4O2S2
 1
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
CP0109923
3-{[1-(4-chlorophenyl)propyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C15H17ClN4O2S2
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0136781
3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C14H15ClN4O2S2
 1
1
IC50 = 96 nM
   TI
   LI
   LO
   TS
CP0501115
5-(carbamoylamino)-3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)sulfanyl]-1,2-thiazole-4-carboxamide
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C14H13ClN4O2S2
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0045140
3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)sulfanyl]-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C15H15ClN4O2S2
 1
1
IC50 = 118 nM
   TI
   LI
   LO
   TS
CP0502050
3-{[1-(4-chlorophenyl)-2-methylpropyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C16H19ClN4O2S2
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0297089
3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C13H13ClN4O2S2
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0340577
3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-ylamino)-1,2-thiazole-4-carboxamide
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C16H13ClN4OS2
 1
1
IC50 = 344 nM
   TI
   LI
   LO
   TS
CP0110136
3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-3-ylamino)-1,2-thiazole-4-carboxamide
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C16H13ClN4OS2
 1
1
IC50 = 581 nM
   TI
   LI
   LO
   TS
CP0110138
3-{[1-(4-chlorophenyl)butyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C16H19ClN4O2S2
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0146125
3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-2-ylamino)-1,2-thiazole-4-carboxamide
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C16H13ClN4OS2
 1
1
IC50 = 756 nM
   TI
   LI
   LO
   TS
CP0136779
3-{[(1S)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C15H17ClN4O2S2
 1
1
IC50 = 978 nM
   TI
   LI
   LO
   TS
CP0552178
5-[(methylcarbamoyl)amino]-3-(1,2,3,4-tetrahydronaphthalen-1-ylsulfanyl)-1,2-thiazole-4-carboxamide
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C16H18N4O2S2
 1
1
IC50 = 1020 nM
   TI
   LI
   LO
   TS
CP0292059
5-(carbamoylamino)-3-(1,2,3,4-tetrahydronaphthalen-1-ylsulfanyl)-1,2-thiazole-4-carboxamide
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C15H16N4O2S2
 1
1
IC50 = 1170 nM
   TI
   LI
   LO
   TS
CP0275029
3-{[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]sulfanyl}-5-[(methylcarbamoyl)amino]-1,2-thiazole-4-carboxamide
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C14H12ClF3N4O2S2
 1
1
IC50 = 2870 nM
   TI
   LI
   LO
   TS
CP0369561
3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(6-methoxypyridin-3-yl)amino]-1,2-thiazole-4-carboxamide
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C17H15ClN4O2S2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0369564
3-[(cyclohexylmethyl)sulfanyl]-5-(pyridin-3-ylamino)-1,2-thiazole-4-carboxamide
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C16H20N4OS2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS