Brief Information of the Cell Line and Protein
Cell Line ID: CL000247 , MT-4
Synonyms
MT4
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_2632
Protein ID: PT00004 , Pol polyprotein
Gene Name POL
Organism Human immunodeficiency virus 1
Protein Classification Enzyme
Uniprot ID Q72874
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000247  Protein ID: PT00004
 
Compound ID Compound Name Compound Formula
CP0914807
3-(2-Ethyl-phenylsulfanyl)-4-hydroxy-6-naphthalen-1-ylmethyl-6-propyl-5,6-dihydro-pyran-2-one
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C27H28O3S
 1
1
EC50 = 1700 nM
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CP0883430
3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-isopropyl-6-phenethyl-5,6-dihydro-pyran-2-one
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C27H34O3S
 2
1
EC50 = 15000 nM
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2
IC50 = 1.1 nM
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CP0281880
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(cyclohexyloxy)(2,3-dihydro-1,4-benzodioxine-6-)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C31H40N2O10S
 3
1
IC50 = 3 nM
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2
IC50 = 100 nM
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3
IC50 > 240 nM
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CP0152284
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(cyclohexyloxy)(4-hydroxybenzene)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C29H38N2O9S
 3
1
IC50 = 5 nM
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2
IC50 = 44 nM
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3
IC50 = 117 nM
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CP0766510
{(1S,2R)-3-[Cyclopentyloxy-(4-methoxy-benzenesulfonyl)-amino]-2-hydroxy-1-phenyl-propyl}-carbamic acid (S)-(hexahydro-furo[2,3-b]furan-3-yl) ester
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C29H38N2O9S
 1
1
IC50 = 6 nM
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CP0166974
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(cyclopentyloxy)(2,3-dihydro-1,4-benzodioxine-6-)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C30H38N2O10S
 3
1
IC50 = 7 nM
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2
IC50 = 184 nM
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3
IC50 = 194 nM
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CP0287358
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[2H-1,3-benzodioxole-5-(cyclopentyloxy)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C29H36N2O10S
 1
1
IC50 = 7 nM
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CP0370605
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(cyclohexyloxy)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C29H39N3O8S
 1
1
IC50 = 8 nM
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CP0225762
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(cyclopentyloxy)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C28H37N3O8S
 3
1
IC50 = 9 nM
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2
IC50 = 212 nM
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3
IC50 > 240 nM
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CP0152282
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(3-aminobenzene)(cyclohexyloxy)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C29H39N3O8S
 1
1
IC50 = 11 nM
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CP0190589
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(cyclopentyloxy)(4-hydroxybenzene)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C28H36N2O9S
 1
1
IC50 = 12 nM
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CP0280762
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[2H-1,3-benzodioxole-5-(cyclohexyloxy)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C30H38N2O10S
 3
1
IC50 = 13 nM
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2
IC50 = 107 nM
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3
IC50 > 240 nM
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CP0306936
4-Hydroxy-3-(2-isopropyl-phenylsulfanyl)-6-m-tolyl-pyran-2-one
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C21H20O3S
 1
1
IC50 = 14 nM
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CP0281913
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(3-aminobenzene)(cyclopentyloxy)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C28H37N3O8S
 1
1
IC50 = 17 nM
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CP0166058
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(cyclopentyloxy)(4-methoxybenzene)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C29H38N2O9S
 1
1
IC50 = 20 nM
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CP0669811
(S)-N*1*-{3-[Cyclopentyloxy-(4-methoxy-benzenesulfonyl)-amino]-2-hydroxy-1-phenyl-propyl}-2-[(quinoline-2-carbonyl)-amino]-succinamide
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C36H41N5O8S
 1
1
IC50 = 24 nM
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CP0777024
4-Hydroxy-6-phenethyl-3-(1-phenyl-propyl)-6-propyl-5,6-dihydro-pyran-2-one
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C25H30O3
 1
1
IC50 = 35 nM
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CP0038005
(3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-methylpropyl)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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C25H35N3O6S
 3
1
IC50 = 150 nM
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2
IC50 = 440 nM
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3
IC50 > 1000 nM
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CP0310135
N-alkoxysulfonamide analog 9
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C30H43N3O8S
 1
1
IC50 = 203 nM
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CP0706790
{(1S,2R)-3-[Cyclopentyloxy-(4-methoxy-benzenesulfonyl)-amino]-2-hydroxy-1-phenyl-propyl}-carbamic acid tetrahydro-furan-3-yl ester
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C27H36N2O8S
 1
1
IC50 = 738 nM
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CP0147413
4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
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C18H16O3
 1
1
IC50 = 1000 nM
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CP0078416
2-Aminobenzyl-Substituted AHPPA deriv. 1
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C45H55N7O7
 1
1
Ki = 3.4 nM
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CP0943593
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((9S,12R)-9-isopropyl-8,11-dioxo-2-oxa-7,10,13-triaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-12-yl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C40H53N5O7
 1
1
Ki = 6.6 nM
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CP0705512
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((13S,16R)-13-isopropyl-12,15-dioxo-2,5,8-trioxa-11,14,17-triaza-bicyclo[17.2.2]tricosa-1(22),19(23),20-trien-16-yl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C42H57N5O9
 1
1
Ki = 6.9 nM
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CP0957247
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((16S,19R)-16-isopropyl-15,18-dioxo-2,5,8,11-tetraoxa-14,17,20-triaza-bicyclo[20.2.2]hexacosa-1(25),22(26),23-trien-19-yl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C44H61N5O10
 1
1
Ki = 7.5 nM
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CP0869076
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.3.1]icosa-1(20),16,18-trien-13-yl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C40H53N5O8
 1
1
Ki = 7.6 nM
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CP0895166
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((13S,16R)-13-isopropyl-12,15-dioxo-2,5,8-trioxa-11,14,17-triaza-bicyclo[17.3.1]tricosa-1(23),19,21-trien-16-yl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C42H57N5O9
 1
1
Ki = 7.7 nM
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CP0798894
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.2.2]icosa-1(19),16(20),17-trien-13-yl)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C40H53N5O8
 1
1
Ki = 7.9 nM
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CP0870011
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.2.2]icosa-1(19),16(20),17-trien-13-yl)-ethylcarbamoyl]-2,2-dimethyl-propyl}-carbamic acid benzyl ester
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C41H55N5O8
 1
1
Ki = 8 nM
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CP0879273
[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.2.2]icosa-1(19),16(20),17-trien-13-yl)-ethyl]-carbamic acid (S)-(tetrahydro-furan-3-yl) ester
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C32H44N4O8
 1
1
Ki = 8.2 nM
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CP0735548
{(S)-1-[(1S,2R,3R)-1-Benzyl-2-hydroxy-3-((R)-(R)-2-hydroxy-indan-1-ylcarbamoyl)-3-(4-methoxy-benzylamino)-propylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
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C41H48N4O7
 1
1
Ki = 9.5 nM
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CP0920496
(S)-N-[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.2.2]icosa-1(19),16(20),17-trien-13-yl)-ethyl]-3,3-dimethyl-2-[2-(4-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetylamino]-butyramide
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C38H54N8O7S
 1
1
Ki = 11.1 nM
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CP0948463
[(1S,2R)-1-Benzyl-2-hydroxy-2-((13S,16R)-13-isopropyl-12,15-dioxo-2,5,8-trioxa-11,14,17-triaza-bicyclo[17.2.2]tricosa-1(22),19(23),20-trien-16-yl)-ethyl]-carbamic acid tert-butyl ester
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C34H50N4O8
 1
1
Ki = 12.6 nM
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CP0892303
[(1S,2R)-1-Benzyl-2-hydroxy-2-((13S,16R)-13-isopropyl-12,15-dioxo-2,5,8-trioxa-11,14,17-triaza-bicyclo[17.2.2]tricosa-1(22),19(23),20-trien-16-yl)-ethyl]-carbamic acid (S)-(tetrahydro-furan-3-yl) ester
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C34H48N4O9
 1
1
Ki = 13.8 nM
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CP0957175
[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.2.2]icosa-1(19),16(20),17-trien-13-yl)-ethyl]-carbamic acid tert-butyl ester
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C32H46N4O7
 1
1
Ki = 14 nM
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CP0943585
[(1S,2R)-1-Benzyl-2-hydroxy-2-((9S,12R)-9-isopropyl-8,11-dioxo-2-oxa-7,10,13-triaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-trien-12-yl)-ethyl]-carbamic acid tert-butyl ester
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C32H46N4O6
 1
1
Ki = 17 nM
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CP0902433
[(1S,2R)-1-Benzyl-2-hydroxy-2-((16S,19R)-16-isopropyl-15,18-dioxo-2,5,8,11-tetraoxa-14,17,20-triaza-bicyclo[20.2.2]hexacosa-1(25),22(26),23-trien-19-yl)-ethyl]-carbamic acid tert-butyl ester
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C36H54N4O9
 1
1
Ki = 23.2 nM
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CP0849746
[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.3.1]icosa-1(20),16,18-trien-13-yl)-ethyl]-carbamic acid tert-butyl ester
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C32H46N4O7
 1
1
Ki = 68.8 nM
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CP0849747
[(1S,2R)-1-Benzyl-2-hydroxy-2-((13S,16R)-13-isopropyl-12,15-dioxo-2,5,8-trioxa-11,14,17-triaza-bicyclo[17.3.1]tricosa-1(23),19,21-trien-16-yl)-ethyl]-carbamic acid tert-butyl ester
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C34H50N4O8
 1
1
Ki = 207.7 nM
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