Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-methylpropyl)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate
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 PubChem ID
CID: 65016
SID: 14884574
Canonical SMILES
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
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Compound Formula C25H35N3O6S
Compound Structure
Protein Name
 Protein Info 
Pol polyprotein
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A2A subfamily
Uniprot ID
Q72874
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
2
IC50 = 440 nM
   TI
   LI
   LO
   TS
3
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1 nM
2 Kd = 1.1 nM
3 Ki = 0.04 nM
4 Ki = 0.057 nM
5 Ki = 0.08 nM
6 Ki < 0.1 nM
7 Ki = 0.1 nM
8 Ki = 0.15 nM
9 Ki = 0.16 nM
10 Ki = 0.17 nM
11 Ki = 0.21 nM
12 Ki = 0.23 nM
13 Ki = 0.6 nM
14 Ki = 1.4 nM
15 Ki = 1.6 nM