General Information of the Compound
Compound ID
CP0870011
Compound Name
{(S)-1-[(1S,2R)-1-Benzyl-2-hydroxy-2-((10S,13R)-10-isopropyl-9,12-dioxo-2,5-dioxa-8,11,14-triaza-bicyclo[14.2.2]icosa-1(19),16(20),17-trien-13-yl)-ethylcarbamoyl]-2,2-dimethyl-propyl}-carbamic acid benzyl ester
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Structure
Formula
C41H55N5O8
Molecular Weight
745.918
Canonical SMILES
CC(C)[C@@H]1NC(=O)[C@@H]([C@H](O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)(C)C)NCc2ccc(cc2)OCCOCCNC1=O
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InChI
InChI=1S/C41H55N5O8/c1-27(2)33-37(48)42-20-21-52-22-23-53-31-18-16-29(17-19-31)25-43-34(38(49)45-33)35(47)32(24-28-12-8-6-9-13-28)44-39(50)36(41(3,4)5)46-40(51)54-26-30-14-10-7-11-15-30/h6-19,27,32-36,43,47H,20-26H2,1-5H3,(H,42,48)(H,44,50)(H,45,49)(H,46,51)/t32-,33-,34+,35+,36+/m0/s1
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InChIKey
TZULDDUNYAGRDC-JFKVGHNISA-N
CAS
180968-42-7
Physicochemical Property
logP
3.2403
Rotatable Bonds
10
Heavy Atom Count
54
Polar Areas
176.35
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
9
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 461294
SID: 15459859
ChEMBL ID
CHEMBL113560
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00004, Pol polyprotein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
Protein ID: PT00064, Protease
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  2
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
2
Ki = 16 nM
   TI
   LI
   LO
   TS