General Information of the Protein
Protein ID
PT00064
Protein Name
Protease
Gene Name
PROTEASE
Sequence
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
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Organism
Human rhinovirus sp
Protein Classification
Enzyme
>
Protease
>
Cysteine protease
>
Cysteine protease PAC clan
>
Cysteine protease C3A subfamily
Uniprot ID
Q4U254
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000133 , H1HeLa
Compound ID Compound Name Compound Formula
CP0184737
3-{3-Carbamoyl-5-[4-(2-cyano-phenyl)-piperazin-1-ylmethyl]-phenyl}-acrylic acid ethyl ester
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C24H26N4O3
 1
1
EC50 = 600 nM
   TI
   LI
   LO
   TS
CP0196844
3-[3-Carbamoyl-5-(4-pyrimidin-2-yl-piperazin-1-ylmethyl)-phenyl]-acrylic acid ethyl ester
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C21H25N5O3
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0364844
4-[3-Carbamoyl-5-(2-ethoxycarbonyl-vinyl)-benzyl]-piperazine-1-carboxylic acid ethyl ester
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C20H27N3O5
 1
1
EC50 = 1800 nM
   TI
   LI
   LO
   TS
CP0270160
3-[3-Carbamoyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-phenyl]-acrylic acid ethyl ester
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C22H26N4O3
 1
1
EC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0196842
3-[3-Carbamoyl-5-(5-pyridin-2-yl-[1,3,4]oxadiazol-2-ylsulfanylmethyl)-phenyl]-acrylic acid ethyl ester
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C20H18N4O4S
 1
1
EC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0279657
3-(3-Carbamoyl-phenyl)-acrylic acid benzyl ester
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C17H15NO3
 1
1
EC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0222225
3-{3-Carbamoyl-5-[(ethyl-pyridin-4-ylmethyl-amino)-methyl]-phenyl}-acrylic acid ethyl ester
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C21H25N3O3
 1
1
EC50 = 5800 nM
   TI
   LI
   LO
   TS
CP0094435
3-(3-Carbamoyl-phenyl)-acrylic acid pyridin-2-ylmethyl ester
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C16H14N2O3
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0400977
3-{3-[(Benzyl-ethoxycarbonylmethyl-amino)-methyl]-5-carbamoyl-phenyl}-acrylic acid ethyl ester
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C24H28N2O5
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0207271
3-[3-(4-Dimethylamino-phenyl)-3-oxo-propenyl]-benzamide
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C18H18N2O2
 1
1
EC50 > 15000 nM
   TI
   LI
   LO
   TS
CP0226699
3-(3-Carbamoyl-phenyl)-acrylic acid ethyl ester
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C12H13NO3
 1
1
EC50 = 15900 nM
   TI
   LI
   LO
   TS
CP0214120
1-Oxo-1H-indene-5-carboxylic acid amide
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C10H7NO2
 1
1
EC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0291160
3-(3-Carbamoyl-phenyl)-acrylic acid 2-hydroxy-ethyl ester
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C12H13NO4
 1
1
EC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0219067
3-[3-(4-Methoxy-phenyl)-3-oxo-propenyl]-benzamide
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C17H15NO3
 1
1
EC50 > 22000 nM
   TI
   LI
   LO
   TS
CP0196981
3-(3-Oxo-3-phenyl-propenyl)-benzamide
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C16H13NO2
 1
1
EC50 = 28000 nM
   TI
   LI
   LO
   TS
CP0723523
3-(3-Oxo-but-1-enyl)-benzamide
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C11H11NO2
 1
1
EC50 = 32000 nM
   TI
   LI
   LO
   TS
CP0238547
3-(3-Oxo-3-pyridin-2-yl-propenyl)-benzamide
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C15H12N2O2
 1
1
EC50 = 50000 nM
   TI
   LI
   LO
   TS
CP0213978
3-(3-Furan-2-yl-3-oxo-propenyl)-benzamide
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C14H11NO3
 1
1
EC50 > 71000 nM
   TI
   LI
   LO
   TS
CP0305872
3-(3-Carbamoyl-phenyl)-acrylic acid phenethyl ester
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C18H17NO3
 1
1
EC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0337777
3-(3-Carbamoyl-phenyl)-2-cyano-acrylic acid ethyl ester
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C13H12N2O3
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0352901
3-(5-Carbamoyl-2-methyl-phenyl)-acrylic acid ethyl ester
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C13H15NO3
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0358170
3-(3-Carbamoyl-5-hydroxymethyl-phenyl)-acrylic acid ethyl ester
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C13H15NO4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0476601
3-(3-Carbamoyl-5-hydroxy-phenyl)-acrylic acid ethyl ester
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C12H13NO4
 1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0098455
(2R,3R,4S)-N-[(1S)-1-[(1H-1,3-benzodiazol-2-ylmethyl)carbamoyl]-2-methylpropyl]-3-hydroxy-4-[(2S)-2-[3-(4-hydroxyphenyl)propanamido]-3,3-dimethylbutanamido]-2-{[(4-methoxyphenyl)methyl]amino}-5-phenylpentanamide
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C47H59N7O7
 1
1 Ki = 63 nM
CP0078416
2-Aminobenzyl-Substituted AHPPA deriv. 1
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C45H55N7O7
 1
1 Ki = 120 nM
CP0214120
1-Oxo-1H-indene-5-carboxylic acid amide
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C10H7NO2
 1
1 Ki = 120 nM
CP0196981
3-(3-Oxo-3-phenyl-propenyl)-benzamide
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C16H13NO2
 1
1 Ki = 400 nM
CP0337777
3-(3-Carbamoyl-phenyl)-2-cyano-acrylic acid ethyl ester
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C13H12N2O3
 1
1 Ki = 1500 nM
CP0219067
3-[3-(4-Methoxy-phenyl)-3-oxo-propenyl]-benzamide
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C17H15NO3
 1
1 Ki = 1800 nM
CP0238547
3-(3-Oxo-3-pyridin-2-yl-propenyl)-benzamide
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C15H12N2O2
 1
1 Ki = 1800 nM
CP0213978
3-(3-Furan-2-yl-3-oxo-propenyl)-benzamide
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C14H11NO3
 1
1 Ki = 1900 nM
CP0207271
3-[3-(4-Dimethylamino-phenyl)-3-oxo-propenyl]-benzamide
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C18H18N2O2
 1
1 Ki = 9000 nM
CP0723523
3-(3-Oxo-but-1-enyl)-benzamide
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C11H11NO2
 1
1 Ki = 25000 nM