General Information of the Compound
Compound ID
CP0364844
Compound Name
4-[3-Carbamoyl-5-(2-ethoxycarbonyl-vinyl)-benzyl]-piperazine-1-carboxylic acid ethyl ester
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Structure
Formula
C20H27N3O5
Molecular Weight
389.452
Canonical SMILES
CCOC(=O)\C=C\c1cc(CN2CCN(CC2)C(=O)OCC)cc(c1)C(N)=O
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InChI
InChI=1S/C20H27N3O5/c1-3-27-18(24)6-5-15-11-16(13-17(12-15)19(21)25)14-22-7-9-23(10-8-22)20(26)28-4-2/h5-6,11-13H,3-4,7-10,14H2,1-2H3,(H2,21,25)/b6-5+
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InChIKey
RTPMZYGAJLJOTP-AATRIKPKSA-N
Physicochemical Property
logP
1.6359
Rotatable Bonds
7
Heavy Atom Count
28
Polar Areas
102.17
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10000404
SID: 14980106
ChEMBL ID
CHEMBL45155
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00064, Protease
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000133 H1HeLa Homo sapiens (Human)  1
1
EC50 = 1800 nM
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