General Information of the Compound
Compound ID
CP0910464
Compound Name
SID103050677
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Structure
Formula
C26H24F3N5O2
Molecular Weight
495.505
Canonical SMILES
CN(C)CCNC(=O)c1cccc(-c2cnc3c(NC=O)cc(-c4cccc(C(F)(F)F)c4)cn23)c1
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InChI
InChI=1S/C26H24F3N5O2/c1-33(2)10-9-30-25(36)19-7-3-6-18(11-19)23-14-31-24-22(32-16-35)13-20(15-34(23)24)17-5-4-8-21(12-17)26(27,28)29/h3-8,11-16H,9-10H2,1-2H3,(H,30,36)(H,32,35)
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InChIKey
RZOHPABQGJVBAL-UHFFFAOYSA-N
Physicochemical Property
logP
4.5468
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
78.74
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49778438
ChEMBL ID
CHEMBL1903878
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 20596.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 9070 nM
   TI
   LI
   LO
   TS