General Information of the Compound
Compound ID
CP0881158
Compound Name
SID50106063
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Synonyms
Cyclobenzaprine very low dose
TNX-102
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Structure
Formula
C20H22ClN
Molecular Weight
311.856
Canonical SMILES
CN(C)CCC=C1c2ccccc2C=Cc2ccccc21.Cl
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InChI
InChI=1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H
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InChIKey
VXEAYBOGHINOKW-UHFFFAOYSA-N
CAS
6202-23-9
Physicochemical Property
logP
4.9756
Rotatable Bonds
3
Heavy Atom Count
22
Polar Areas
3.24
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57515965
SID: 12015332
ChEMBL ID
CHEMBL1200636
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 3264.3 nM
   TI
   LI
   LO
   TS
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 16360.1 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( TNX-102 )
Drug Name TNX-102
Company TONIX Pharmaceuticals
Indication
Fibromyalgia
Phase 3
Post-traumatic stress disorder
Phase 3
Target(s)
Adrenergic receptor alpha-2C (ADRA2C)
Antagonist
5-HT 2A receptor (HTR2A)
Antagonist