General Information of the Compound
Compound ID
CP0875064
Compound Name
2-[3-(Imidazol-4-yl)-propyl]-1-(benzyl)-isothioureadihydrobromide
    Show/Hide
Structure
Formula
C14H20Br2N4S
Molecular Weight
436.217
Canonical SMILES
Br.Br.N=C(NCc1ccccc1)SCCCc1c[nH]cn1
    Show/Hide
InChI
InChI=1S/C14H18N4S.2BrH/c15-14(17-9-12-5-2-1-3-6-12)19-8-4-7-13-10-16-11-18-13;;/h1-3,5-6,10-11H,4,7-9H2,(H2,15,17)(H,16,18);2*1H
    Show/Hide
InChIKey
KOMQNGMOYJEHAD-UHFFFAOYSA-N
Physicochemical Property
logP
3.95587
Rotatable Bonds
6
Heavy Atom Count
21
Polar Areas
64.56
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 49860096
ChEMBL ID
CHEMBL1202324
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 7.943 nM
   TI
   LI
   LO
   TS
Protein ID: PT01711, Histamine H4 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  2
1
Kd = 19.95 nM
   TI
   LI
   LO
   TS
2
Ki = 25.12 nM
   TI
   LI
   LO
   TS