General Information of the Compound
Compound ID
CP0848977
Compound Name
2-Methyl-6-(4-methylpiperazin-1-yl)-9-tetrahydropyran-4-yl-8-[2-(trifluoromethyl)phenyl]purine Hydrochloride
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Structure
Formula
C23H28ClF3N6O
Molecular Weight
496.965
Canonical SMILES
Cc1nc(N2CCN(C)CC2)c2nc(-c3ccccc3C(F)(F)F)n(C3CCOCC3)c2n1.Cl
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InChI
InChI=1S/C23H27F3N6O.ClH/c1-15-27-21(31-11-9-30(2)10-12-31)19-22(28-15)32(16-7-13-33-14-8-16)20(29-19)17-5-3-4-6-18(17)23(24,25)26;/h3-6,16H,7-14H2,1-2H3;1H
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InChIKey
RKBMMCQSHOXMNV-UHFFFAOYSA-N
Physicochemical Property
logP
4.34562
Rotatable Bonds
3
Heavy Atom Count
34
Polar Areas
59.31
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68603806
ChEMBL ID
CHEMBL3092903
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01298, Cannabinoid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00834, Cannabinoid receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 13.6 nM
   TI
   LI
   LO
   TS
2
Ki = 62.8 nM
   TI
   LI
   LO
   TS
Protein ID: PT02333, Cannabinoid receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 40.4 nM
   TI
   LI
   LO
   TS