General Information of the Compound
Compound ID
CP0548340
Compound Name
10-[[4-(hydroxycarbamoyl)phenyl]methyl]-N-(5-methylpyridin-2-yl)phenothiazine-2-carboxamide
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Formula
C27H22N4O3S
Molecular Weight
482.565
Canonical SMILES
Cc1ccc(NC(=O)c2ccc3Sc4ccccc4N(Cc4ccc(cc4)C(=O)NO)c3c2)nc1
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InChI
InChI=1S/C27H22N4O3S/c1-17-6-13-25(28-15-17)29-26(32)20-11-12-24-22(14-20)31(21-4-2-3-5-23(21)35-24)16-18-7-9-19(10-8-18)27(33)30-34/h2-15,34H,16H2,1H3,(H,30,33)(H,28,29,32)
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InChIKey
ZDGSWCNMNJYQEI-UHFFFAOYSA-N
Physicochemical Property
logP
5.56422
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
94.56
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4861336
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00994, Histone deacetylase 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 3810 nM
   TI
   LI
   LO
   TS
Protein ID: PT01213, Histone deacetylase 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 395.67 nM
   TI
   LI
   LO
   TS
Protein ID: PT01807, Histone deacetylase 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
Protein ID: PT01946, Histone deacetylase 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS