General Information of the Compound
Compound ID
CP0540779
Compound Name
N-[3-(4-tert-butylphenyl)-5,6-dichloro-2-oxo-1H-indol-3-yl]-2-(4-methylpiperazin-1-yl)acetamide
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Structure
Formula
C25H30Cl2N4O2
Molecular Weight
489.447
Canonical SMILES
CN1CCN(CC(=O)NC2(C(=O)Nc3cc(Cl)c(Cl)cc23)c2ccc(cc2)C(C)(C)C)CC1
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InChI
InChI=1S/C25H30Cl2N4O2/c1-24(2,3)16-5-7-17(8-6-16)25(29-22(32)15-31-11-9-30(4)10-12-31)18-13-19(26)20(27)14-21(18)28-23(25)33/h5-8,13-14H,9-12,15H2,1-4H3,(H,28,33)(H,29,32)
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InChIKey
GMPYEOWYKXIMNB-UHFFFAOYSA-N
Physicochemical Property
logP
3.8502
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
64.68
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71460564
ChEMBL ID
CHEMBL2164492
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01155, Growth hormone secretagogue receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000643 CHO-K1/CRE-Luc Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1470 nM
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