General Information of the Compound
Compound ID
CP0525119
Compound Name
US9139578, 22
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Structure
Formula
C28H17F4N5O4S2
Molecular Weight
627.601
Canonical SMILES
Fc1cc(cc2sc(nc12)C(NC(=O)c1ccc(cc1)C(F)(F)F)c1nnc(CC2SC(=O)NC2=O)o1)-c1ccccc1
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InChI
InChI=1S/C28H17F4N5O4S2/c29-17-10-15(13-4-2-1-3-5-13)11-18-21(17)34-26(42-18)22(33-23(38)14-6-8-16(9-7-14)28(30,31)32)25-37-36-20(41-25)12-19-24(39)35-27(40)43-19/h1-11,19,22H,12H2,(H,33,38)(H,35,39,40)
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InChIKey
VQEZCWFFNWZZTN-UHFFFAOYSA-N
Physicochemical Property
logP
5.9177
Rotatable Bonds
7
Heavy Atom Count
43
Polar Areas
127.08
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 72945014
ChEMBL ID
CHEMBL3916517
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01303, Endothelial lipase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
IC50 < 10 nM
   TI
   LI
   LO
   TS