General Information of the Compound
Compound ID
CP0508249
Compound Name
N-[4-[4-(5-methoxy-1,2-benzoxazol-3-yl)piperazin-1-yl]butyl]quinoxaline-6-carboxamide
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Structure
Formula
C25H28N6O3
Molecular Weight
460.538
Canonical SMILES
COc1ccc2onc(N3CCN(CCCCNC(=O)c4ccc5nccnc5c4)CC3)c2c1
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InChI
InChI=1S/C25H28N6O3/c1-33-19-5-7-23-20(17-19)24(29-34-23)31-14-12-30(13-15-31)11-3-2-8-28-25(32)18-4-6-21-22(16-18)27-10-9-26-21/h4-7,9-10,16-17H,2-3,8,11-15H2,1H3,(H,28,32)
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InChIKey
XACDTORTLZTQDA-UHFFFAOYSA-N
Physicochemical Property
logP
3.1118
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
96.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11505572
SID: 16612829
ChEMBL ID
CHEMBL199746
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
Ki > 750 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 220 nM
   TI
   LI
   LO
   TS