General Information of the Compound
Compound ID
CP0483807
Compound Name
(2S)-N-[(2S)-3-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopropan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-(cyclohexylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
    Show/Hide
Synonyms
CHEMBL375187
D[Cha4,Dap8]VP
d[Cha4,Dap8]VP
    Show/Hide
Structure
Formula
C47H65N11O11S2
Molecular Weight
1024.237
Canonical SMILES
NC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
    Show/Hide
InChI
InChI=1S/C47H65N11O11S2/c48-24-35(41(63)51-25-39(50)61)56-46(68)37-12-7-18-58(37)47(69)36-26-71-70-19-17-40(62)52-31(22-29-13-15-30(59)16-14-29)42(64)53-32(20-27-8-3-1-4-9-27)43(65)54-33(21-28-10-5-2-6-11-28)44(66)55-34(23-38(49)60)45(67)57-36/h1,3-4,8-9,13-16,28,31-37,59H,2,5-7,10-12,17-26,48H2,(H2,49,60)(H2,50,61)(H,51,63)(H,52,62)(H,53,64)(H,54,65)(H,55,66)(H,56,68)(H,57,67)/t31-,32-,33-,34-,35-,36-,37-/m0/s1
    Show/Hide
InChIKey
XABCPBOFMBSCDK-PEAOEFARSA-N
Physicochemical Property
logP
-1.7317
Rotatable Bonds
15
Heavy Atom Count
71
Polar Areas
356.44
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
14
Complexity
71

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 16109439
SID: 24756219
ChEMBL ID
CHEMBL375187
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01510, Oxytocin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
Protein ID: PT03188, Vasopressin V1b receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000367 AtT-20 Mus musculus (Mouse)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( D[Cha4,Dap8]VP )
Drug Name D[Cha4,Dap8]VP
Target(s)
Vasopressin V1a receptor (V1AR)
Inhibitor
Vasopressin V1b receptor (V1BR)
Inhibitor
Oxytocin receptor (OTR)
Inhibitor
Vasopressin V2 receptor (V2R)
Inhibitor