General Information of the Compound
Compound ID
CP0476016
Compound Name
1-[4-[1-adamantyl(phenyl)methyl]phenyl]piperazine
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Structure
Formula
C27H34N2
Molecular Weight
386.583
Canonical SMILES
C1CN(CCN1)c1ccc(cc1)C(c1ccccc1)C12CC3CC(CC(C3)C1)C2
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InChI
InChI=1S/C27H34N2/c1-2-4-23(5-3-1)26(27-17-20-14-21(18-27)16-22(15-20)19-27)24-6-8-25(9-7-24)29-12-10-28-11-13-29/h1-9,20-22,26,28H,10-19H2
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InChIKey
HBXNTQUIWJGXNY-UHFFFAOYSA-N
Physicochemical Property
logP
5.4445
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
15.27
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 70683538
ChEMBL ID
CHEMBL2023827
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01509, Sigma non-opioid intracellular receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 12.4 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000145 NCI-H460 Homo sapiens (Human)  2
1
GI50 = 3740 nM
   TI
   LI
   LO
   TS
2
LC50 = 9700 nM
   TI
   LI
   LO
   TS
CL000423 IGROV-1 Homo sapiens (Human)  2
1
GI50 = 3320 nM
   TI
   LI
   LO
   TS
2
LC50 = 8890 nM
   TI
   LI
   LO
   TS
CL000561 LOX-IMVI Homo sapiens (Human)  2
1
GI50 = 2790 nM
   TI
   LI
   LO
   TS
2
LC50 = 8110 nM
   TI
   LI
   LO
   TS
CL000749 HUVEC-C Homo sapiens (Human)  2
1
GI50 = 4800 nM
   TI
   LI
   LO
   TS
2
LC50 = 100000 nM
   TI
   LI
   LO
   TS