General Information of the Compound
Compound ID
CP0464172
Compound Name
2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-N-furan-2-ylmethyl-isonicotinamide
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Structure
Formula
C29H31N3O4
Molecular Weight
485.584
Canonical SMILES
O=C(COc1ccc(cc1)C12CC3CC(CC(C3)C1)C2)Nc1cc(ccn1)C(=O)NCc1ccco1
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InChI
InChI=1S/C29H31N3O4/c33-27(32-26-13-22(7-8-30-26)28(34)31-17-25-2-1-9-35-25)18-36-24-5-3-23(4-6-24)29-14-19-10-20(15-29)12-21(11-19)16-29/h1-9,13,19-21H,10-12,14-18H2,(H,31,34)(H,30,32,33)
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InChIKey
FJOKEPFTMZTYDS-UHFFFAOYSA-N
Physicochemical Property
logP
5.0899
Rotatable Bonds
8
Heavy Atom Count
36
Polar Areas
93.46
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44443251
ChEMBL ID
CHEMBL398897
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02791, Hypoxia-inducible factor 1-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000273 Hep 3B2.1-7 Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CL000274 SK-HEP-1 Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CL000275 AGS Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS