General Information of the Compound
Compound ID
CP0453132
Compound Name
6-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-6-N-prop-2-ynyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
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Synonyms
BDBM50261302
CHEMBL513352
D-218
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Structure
Formula
C23H31N5OS
Molecular Weight
425.602
Canonical SMILES
COc1ccccc1N1CCN(CCN(CC#C)C2CCc3nc(N)sc3C2)CC1
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InChI
InChI=1S/C23H31N5OS/c1-3-10-27(18-8-9-19-22(17-18)30-23(24)25-19)14-11-26-12-15-28(16-13-26)20-6-4-5-7-21(20)29-2/h1,4-7,18H,8-17H2,2H3,(H2,24,25)
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InChIKey
GUCAXHFLECNGRL-UHFFFAOYSA-N
Physicochemical Property
logP
2.3486
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
57.86
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44577151
ChEMBL ID
CHEMBL513352
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 81.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT01366, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 34.8 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( D-218 )
Drug Name D-218
Target(s)
Dopamine D3 receptor (D3R)
Inhibitor
Dopamine D2 receptor (D2R)
Inhibitor