General Information of the Compound
Compound ID
CP0435950
Compound Name
(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-(cyclohexylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
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Synonyms
CHEMBL221485
D[Cha4,Lys8]VP
d[Cha4,Lys8]VP
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Structure
Formula
C50H71N11O11S2
Molecular Weight
1066.318
Canonical SMILES
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
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InChI
InChI=1S/C50H71N11O11S2/c51-21-8-7-14-34(44(66)54-28-42(53)64)56-49(71)40-15-9-22-61(40)50(72)39-29-74-73-23-20-43(65)55-35(26-32-16-18-33(62)19-17-32)45(67)57-36(24-30-10-3-1-4-11-30)46(68)58-37(25-31-12-5-2-6-13-31)47(69)59-38(27-41(52)63)48(70)60-39/h1,3-4,10-11,16-19,31,34-40,62H,2,5-9,12-15,20-29,51H2,(H2,52,63)(H2,53,64)(H,54,66)(H,55,65)(H,56,71)(H,57,67)(H,58,68)(H,59,69)(H,60,70)/t34-,35-,36-,37-,38-,39-,40-/m0/s1
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InChIKey
RJWLIPGRNZUUNS-OAKHNGAUSA-N
Physicochemical Property
logP
-0.5614
Rotatable Bonds
18
Heavy Atom Count
74
Polar Areas
356.44
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
14
Complexity
74

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16109437
SID: 24756217
ChEMBL ID
CHEMBL221485
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01510, Oxytocin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 590 nM
   TI
   LI
   LO
   TS
Protein ID: PT03188, Vasopressin V1b receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000367 AtT-20 Mus musculus (Mouse)  1
1
Ki = 1.9 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( D[Cha4,Lys8]VP )
Drug Name D[Cha4,Lys8]VP
Target(s)
Vasopressin V1a receptor (V1AR)
Inhibitor
Oxytocin receptor (OTR)
Inhibitor
Vasopressin V1b receptor (V1BR)
Inhibitor
Vasopressin V2 receptor (V2R)
Inhibitor