General Information of the Compound
Compound ID
CP0419103
Compound Name
6-(5-Methoxypyridin-3-yl)-3,4-dihydronaphthalen-2(1H)-one
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Structure
Formula
C16H15NO2
Molecular Weight
253.301
Canonical SMILES
COc1cncc(c1)-c1ccc2CC(=O)CCc2c1
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InChI
InChI=1S/C16H15NO2/c1-19-16-8-14(9-17-10-16)12-2-3-13-7-15(18)5-4-11(13)6-12/h2-3,6,8-10H,4-5,7H2,1H3
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InChIKey
VMXXQQUNEIDJSC-UHFFFAOYSA-N
Physicochemical Property
logP
2.815
Rotatable Bonds
2
Heavy Atom Count
19
Polar Areas
39.19
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25180500
SID: 57286806
ChEMBL ID
CHEMBL499007
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03119, Cytochrome P450 11B1, mitochondrial
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000170 V79MZ Cricetulus griseus (Chinese hamster)  1
1
IC50 = 191 nM
   TI
   LI
   LO
   TS
Protein ID: PT03120, Cytochrome P450 11B2, mitochondrial
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000170 V79MZ Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1.8 nM
   TI
   LI
   LO
   TS