General Information of the Compound
Compound ID
CP0411110
Compound Name
5,5-diphenyl-3-[[4-(3-piperidin-1-ylpropoxy)phenyl]methyl]imidazolidine-2,4-dione
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Structure
Formula
C30H33N3O3
Molecular Weight
483.612
Canonical SMILES
O=C1NC(C(=O)N1Cc1ccc(OCCCN2CCCCC2)cc1)(c1ccccc1)c1ccccc1
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InChI
InChI=1S/C30H33N3O3/c34-28-30(25-11-4-1-5-12-25,26-13-6-2-7-14-26)31-29(35)33(28)23-24-15-17-27(18-16-24)36-22-10-21-32-19-8-3-9-20-32/h1-2,4-7,11-18H,3,8-10,19-23H2,(H,31,35)
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InChIKey
MXRUKGSLFINORK-UHFFFAOYSA-N
Physicochemical Property
logP
4.937
Rotatable Bonds
9
Heavy Atom Count
36
Polar Areas
61.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90654503
ChEMBL ID
CHEMBL3238447
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01206, Histamine H1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2238.72 nM
   TI
   LI
   LO
   TS
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 75.86 nM
   TI
   LI
   LO
   TS
Protein ID: PT01711, Histamine H4 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 9332.54 nM
   TI
   LI
   LO
   TS