General Information of the Compound
Compound ID
CP0407869
Compound Name
7-methoxy-N-(4-(4-(7-methoxyisoquinolin-1-yl)piperazin-1-yl)butyl)benzofuran-2-carboxamide
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Structure
Formula
C28H32N4O4
Molecular Weight
488.588
Canonical SMILES
COc1ccc2ccnc(N3CCN(CCCCNC(=O)c4cc5cccc(OC)c5o4)CC3)c2c1
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InChI
InChI=1S/C28H32N4O4/c1-34-22-9-8-20-10-12-29-27(23(20)19-22)32-16-14-31(15-17-32)13-4-3-11-30-28(33)25-18-21-6-5-7-24(35-2)26(21)36-25/h5-10,12,18-19H,3-4,11,13-17H2,1-2H3,(H,30,33)
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InChIKey
IKWFRNZOZWEGCD-UHFFFAOYSA-N
Physicochemical Property
logP
4.3304
Rotatable Bonds
9
Heavy Atom Count
36
Polar Areas
80.07
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11547643
SID: 16649801
ChEMBL ID
CHEMBL201027
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
Ki = 519 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 102 nM
   TI
   LI
   LO
   TS