General Information of the Compound
Compound ID
CP0407187
Compound Name
(1S,4R,4aS,6S,6aR,9R,11aS,11bS)-1-acetoxy-6-hydroxy-4,11b-dimethyl-8-methylene-7-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
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Structure
Formula
C22H30O6
Molecular Weight
390.476
Canonical SMILES
CC(=O)O[C@H]1CC[C@](C)([C@H]2C[C@H](O)[C@@]34C[C@@H](CC[C@H]3[C@]12C)C(=C)C4=O)C(O)=O
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InChI
InChI=1S/C22H30O6/c1-11-13-5-6-14-21(4)15(9-16(24)22(14,10-13)18(11)25)20(3,19(26)27)8-7-17(21)28-12(2)23/h13-17,24H,1,5-10H2,2-4H3,(H,26,27)/t13-,14+,15-,16+,17+,20-,21+,22-/m1/s1
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InChIKey
ZTVNRCQJNOFPGA-MQAARBLVSA-N
Physicochemical Property
logP
2.7315
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
100.9
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 51361444
SID: 136886329
ChEMBL ID
CHEMBL1902074
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 6513.1 nM
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Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 4070 nM
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