General Information of the Compound
Compound ID
CP0403763
Compound Name
N-methyl-4-[[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]methyl]benzamide
    Show/Hide
Structure
Formula
C27H28N6O3
Molecular Weight
484.56
Canonical SMILES
CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc34)CC2)cc1
    Show/Hide
InChI
InChI=1S/C27H28N6O3/c1-28-26(35)20-10-8-19(9-11-20)17-31-13-15-32(16-14-31)18-24(34)33-23-7-3-2-5-21(23)27(36)30-22-6-4-12-29-25(22)33/h2-12H,13-18H2,1H3,(H,28,35)(H,30,36)
    Show/Hide
InChIKey
ZJSOFJRIJVTWTE-UHFFFAOYSA-N
Physicochemical Property
logP
2.4894
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
97.88
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 15050946
ChEMBL ID
CHEMBL304391
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01913, Muscarinic acetylcholine receptor M1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000398 A-9 Mus musculus (Mouse)  1
1
Ki = 2840 nM
   TI
   LI
   LO
   TS
Protein ID: PT01713, Muscarinic acetylcholine receptor M3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000398 A-9 Mus musculus (Mouse)  1
1
Ki = 4020 nM
   TI
   LI
   LO
   TS
Protein ID: PT01736, Muscarinic acetylcholine receptor M4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000047 108CC15 Mus musculus (Mouse)--NCBI_TaxID=10116;  1
1
Ki = 2940 nM
   TI
   LI
   LO
   TS