General Information of the Protein
Protein ID
PT01913
Protein Name
Muscarinic acetylcholine receptor M1
Gene Name
CHRM1
Secondarily
Gene Name
Chrm-1
Sequence
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Acetylcholine receptor
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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Uniprot ID
P08482
Ensembl ID
ENSG00000168539
Subcellular Location
Cell membrane
Postsynaptic cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000398 , A-9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0055122
 Compound Info 
CAS_80880-90-6
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C19H22N4O2S
  1
1
Ki = 1.8 nM
 Bioactivity Info 
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CP0453946
 Compound Info 
11-{2-[4-(10-Diethylamino-decyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C32H48N6O2
  1
1
Ki = 3 nM
 Bioactivity Info 
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CP0409457
 Compound Info 
11-(2-{4-[10-(2-Methoxy-benzylamino)-decyl]-piperazin-1-yl}-acetyl)-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C36H48N6O3
  1
1
Ki = 3.3 nM
 Bioactivity Info 
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CP0408848
 Compound Info 
11-{2-[4-(10-Amino-decyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C28H40N6O2
  1
1
Ki = 15.8 nM
 Bioactivity Info 
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CP0471999
 Compound Info 
2-(6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-hexyl)-isoindole-1,3-dione
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C32H34N6O4
  1
1
Ki = 18 nM
 Bioactivity Info 
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CP0453431
 Compound Info 
11-{2-[4-(8-Amino-octyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C26H36N6O2
  1
1
Ki = 20 nM
 Bioactivity Info 
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CP0437473
 Compound Info 
11-{2-[4-(9-Amino-nonyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C27H38N6O2
  1
1
Ki = 24 nM
 Bioactivity Info 
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CP0056034
 Compound Info 
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
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C19H21N5O2
  1
1
Ki = 29 nM
 Bioactivity Info 
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CP0384751
 Compound Info 
(6-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-hexyl)-carbamic acid tert-butyl ester
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C29H40N6O4
  1
1
Ki = 37.1 nM
 Bioactivity Info 
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CP0402507
 Compound Info 
N-[9-[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]nonyl]acetamide
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C29H40N6O3
  1
1
Ki = 52 nM
 Bioactivity Info 
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CP0406343
 Compound Info 
11-{2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C20H22ClN5O2
  1
1
Ki = 52 nM
 Bioactivity Info 
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CP0430186
 Compound Info 
2-(5-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-pentyl)-isoindole-1,3-dione
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C31H32N6O4
  1
1
Ki = 60 nM
 Bioactivity Info 
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CP0427214
 Compound Info 
11-{2-[4-(7-Amino-heptyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C25H34N6O2
  1
1
Ki = 66 nM
 Bioactivity Info 
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CP0409620
 Compound Info 
N-[10-[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]decyl]acetamide
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C30H42N6O3
  1
1
Ki = 75 nM
 Bioactivity Info 
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CP0508633
 Compound Info 
2-(4-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-butyl)-isoindole-1,3-dione
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C30H30N6O4
  1
1
Ki = 170 nM
 Bioactivity Info 
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CP0440213
 Compound Info 
11-[2-(4-Benzyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C25H25N5O2
  1
1
Ki = 330 nM
 Bioactivity Info 
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CP0406182
 Compound Info 
2-(2-piperazin-1-ylacetyl)-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one
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C17H18N6O2
  1
1
Ki = 370 nM
 Bioactivity Info 
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CP0402515
 Compound Info 
N-[2-[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]ethyl]acetamide
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C22H26N6O3
  1
1
Ki = 670 nM
 Bioactivity Info 
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CP0457427
 Compound Info 
11-{2-[4-(5-Amino-pentyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C23H30N6O2
  1
1
Ki = 1170 nM
 Bioactivity Info 
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CP0457434
 Compound Info 
11-{2-[4-(2-Amino-ethyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C20H24N6O2
  1
1
Ki = 1190 nM
 Bioactivity Info 
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CP0430187
 Compound Info 
11-{2-[4-(6-Amino-hexyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C24H32N6O2
  1
1
Ki = 1310 nM
 Bioactivity Info 
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CP0402503
 Compound Info 
N-(2-aminoethyl)-4-[[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]methyl]benzamide
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C28H31N7O3
  1
1
Ki = 1390 nM
 Bioactivity Info 
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CP0441785
 Compound Info 
11-[2-(4-Prop-2-ynyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C21H21N5O2
  1
1
Ki = 1670 nM
 Bioactivity Info 
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CP0403862
 Compound Info 
tert-butyl N-[4-[[4-[[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]methyl]benzoyl]amino]butyl]carbamate
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C35H43N7O5
  1
1
Ki = 1680 nM
 Bioactivity Info 
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CP0384753
 Compound Info 
2-(3-{4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-propyl)-isoindole-1,3-dione
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C29H28N6O4
  1
1
Ki = 1810 nM
 Bioactivity Info 
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CP0403763
 Compound Info 
N-methyl-4-[[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]methyl]benzamide
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C27H28N6O3
  1
1
Ki = 2840 nM
 Bioactivity Info 
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CP0437410
 Compound Info 
11-{2-[4-(4-Amino-butyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C22H28N6O2
  1
1
Ki = 3080 nM
 Bioactivity Info 
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CP0453207
 Compound Info 
11-{2-[4-(3-Amino-propyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C21H26N6O2
  1
1
Ki = 3870 nM
 Bioactivity Info 
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CP0427347
 Compound Info 
3-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-ethyl)-propionamide
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C23H29N7O3
  1
1
Ki = 4340 nM
 Bioactivity Info 
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CP0453131
 Compound Info 
9-Hydroxymethyl-11-[2-(4-methyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C20H23N5O3
  1
1
Ki = 4400 nM
 Bioactivity Info 
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CP0455134
 Compound Info 
11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-8-methylsulfanyl-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C20H23N5O2S
  1
1
Ki = 4660 nM
 Bioactivity Info 
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CP0493507
 Compound Info 
tert-butyl N-[4-oxo-4-[2-[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]ethylamino]butyl]carbamate
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C29H39N7O5
  1
1
Ki = 4800 nM
 Bioactivity Info 
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CP0402490
 Compound Info 
11-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-acetyl}-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C20H23N5O3
  1
1
Ki = 5800 nM
 Bioactivity Info 
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CP0453230
 Compound Info 
5-Ethyl-11-[2-(4-methyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C21H25N5O2
  1
1
Ki = 7700 nM
 Bioactivity Info 
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CP0448531
 Compound Info 
7-{11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-5-yl}-heptanenitrile
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C26H32N6O2
  1
1
Ki = 8900 nM
 Bioactivity Info 
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CP0399996
 Compound Info 
4-Amino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-ethyl)-butyramide
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C24H31N7O3
  1
1
Ki = 9530 nM
 Bioactivity Info 
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CP0391379
 Compound Info 
4-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-ethyl)-butyramide
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C26H33N7O4
  1
1
Ki = 9650 nM
 Bioactivity Info 
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CP0504150
 Compound Info 
tert-butyl N-[3-oxo-3-[2-[4-[2-oxo-2-(6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazin-1-yl]ethylamino]propyl]carbamate
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C28H37N7O5
  1
1
Ki = 13300 nM
 Bioactivity Info 
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CP0416042
 Compound Info 
(2-{11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11-dihydro-5H-benzo[e]pyrido[3,2-b][1,4]diazepine-8-sulfonylamino}-ethyl)-carbamic acid tert-butyl ester
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C26H35N7O6S
  1
1
Ki > 30000 nM
 Bioactivity Info 
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CP0453537
 Compound Info 
11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11-dihydro-5H-benzo[e]pyrido[3,2-b][1,4]diazepine-8-sulfonic acid (2-amino-ethyl)-amide
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C21H27N7O4S
  1
1
Ki > 30000 nM
 Bioactivity Info 
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CP0462831
 Compound Info 
N-[2-[[11-[2-(4-methylpiperazin-1-yl)acetyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-8-yl]sulfonylamino]ethyl]acetamide
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C23H29N7O5S
  1
1
Ki > 30000 nM
 Bioactivity Info 
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CP0524164
 Compound Info 
11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-6-oxo-6,11-dihydro-5H-benzo[e]pyrido[3,2-b][1,4]diazepine-8-sulfonic acid amide
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C19H22N6O4S
  1
1
Ki > 30000 nM
 Bioactivity Info 
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CP0472255
 Compound Info 
9-(tert-Butyl-dimethyl-silanyloxymethyl)-11-[2-(4-methyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C26H37N5O3Si
  1
1
Ki > 30000 nM
 Bioactivity Info 
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CP0403855
 Compound Info 
3-Acetylamino-N-(2-{4-[2-oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazin-1-yl}-ethyl)-propionamide
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C25H31N7O4
  1
1
Ki = 39400 nM
 Bioactivity Info 
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CP0427351
 Compound Info 
4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide
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C25H24N6O2S
  1
1
Ki > 100000 nM
 Bioactivity Info 
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CP0436010
 Compound Info 
11-[2-(4-Acetyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C20H21N5O3
  1
1
Ki > 100000 nM
 Bioactivity Info 
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CP0490155
 Compound Info 
11-[2-(4-Benzoyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C25H23N5O3
  1
1
Ki > 100000 nM
 Bioactivity Info 
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CP0497274
 Compound Info 
11-[2-(4-Methanesulfonyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one
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C19H21N5O4S
  1
1
Ki > 100000 nM
 Bioactivity Info 
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Cell Line ID: CL000011 , CHO
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0020189
 Compound Info 
6-acetoxy-8-azonia-bicyclo[3.2.1]octane
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C9H15NO2
  2
1 Ki = 5.6 nM
2 Ki = 22000 nM
CP0056034
 Compound Info 
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
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C19H21N5O2
  1
1 Ki = 6.457 nM
CP0054630
 Compound Info 
((2S,4R,5S)-4-Hydroxy-5-methyl-tetrahydro-furan-2-ylmethyl)-trimethyl-ammonium
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C9H20NO2+
  1
1 Ki = 27 nM
CP0635477
 Compound Info 
(2-Carbamoyloxy-ethyl)-trimethyl-ammonium chloride
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C6H15ClN2O2
  1
1 Ki = 31 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01310 Muscarinic acetylcholine receptor M1 Homo sapiens, Human
 Protein Info 
PT03415 Muscarinic acetylcholine receptor M1 Mus musculus, Mouse
 Protein Info