General Information of the Compound
Compound ID
CP0398766
Compound Name
methyl 14-benzyl-5-[4-(trifluoromethyl)phenyl]-2,3,7-triazatricyclo[7.5.0.02,6]tetradeca-1(9),3,5,7-tetraene-14-carboxylate
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Structure
Formula
C27H24F3N3O2
Molecular Weight
479.502
Canonical SMILES
COC(=O)C1(Cc2ccccc2)CCCCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F
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InChI
InChI=1S/C27H24F3N3O2/c1-35-25(34)26(15-18-7-3-2-4-8-18)14-6-5-9-20-16-31-24-22(17-32-33(24)23(20)26)19-10-12-21(13-11-19)27(28,29)30/h2-4,7-8,10-13,16-17H,5-6,9,14-15H2,1H3
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InChIKey
FWRGXFLXKLDHSF-UHFFFAOYSA-N
Physicochemical Property
logP
5.795
Rotatable Bonds
4
Heavy Atom Count
35
Polar Areas
56.49
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118720410
ChEMBL ID
CHEMBL3354782
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 74 nM
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