General Information of the Compound
Compound ID
CP0396392
Compound Name
1-[2-[4-[1-adamantyl(phenyl)methyl]phenyl]ethyl]-4-methylpiperazine
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Structure
Formula
C30H40N2
Molecular Weight
428.664
Canonical SMILES
CN1CCN(CCc2ccc(cc2)C(c2ccccc2)C23CC4CC(CC(C4)C2)C3)CC1
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InChI
InChI=1S/C30H40N2/c1-31-13-15-32(16-14-31)12-11-23-7-9-28(10-8-23)29(27-5-3-2-4-6-27)30-20-24-17-25(21-30)19-26(18-24)22-30/h2-10,24-26,29H,11-22H2,1H3
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InChIKey
LYYKTBPUPZEIDM-UHFFFAOYSA-N
Physicochemical Property
logP
5.8248
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
6.48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71459491
ChEMBL ID
CHEMBL2204672
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01509, Sigma non-opioid intracellular receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 2.9 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  2
1
GI50 = 2.77 nM
   TI
   LI
   LO
   TS
2
LC50 = 8.6 nM
   TI
   LI
   LO
   TS
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
GI50 = 7.5 nM
   TI
   LI
   LO
   TS
CL000274 SK-HEP-1 Homo sapiens (Human)  1
1
LC50 = 9.02 nM
   TI
   LI
   LO
   TS
CL000423 IGROV-1 Homo sapiens (Human)  1
1
GI50 = 4.29 nM
   TI
   LI
   LO
   TS
CL000708 OVCAR-5 Homo sapiens (Human)  1
1
GI50 = 17.35 nM
   TI
   LI
   LO
   TS