General Information of the Compound
Compound ID
CP0389777
Compound Name
1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]pyrrolidine-3-carboxylic acid;hydrochloride
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Structure
Formula
C27H33ClFN3O5
Molecular Weight
534.028
Canonical SMILES
Cl.CCOc1cc(CN2CC3(C2)CC(=NO3)N2CCC(C2)C(O)=O)cc(OCC)c1-c1ccc(F)cc1
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InChI
InChI=1S/C27H32FN3O5.ClH/c1-3-34-22-11-18(12-23(35-4-2)25(22)19-5-7-21(28)8-6-19)14-30-16-27(17-30)13-24(29-36-27)31-10-9-20(15-31)26(32)33;/h5-8,11-12,20H,3-4,9-10,13-17H2,1-2H3,(H,32,33);1H
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InChIKey
FWTACYVVURLFSR-UHFFFAOYSA-N
Physicochemical Property
logP
4.4066
Rotatable Bonds
8
Heavy Atom Count
37
Polar Areas
83.83
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137642090
ChEMBL ID
CHEMBL4088598
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06443, Somatostatin receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
Protein ID: PT01196, Somatostatin receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS