General Information of the Protein
Protein ID
PT06443
Protein Name
Somatostatin receptor type 5
Gene Name
SSTR5
Secondarily
Gene Name
Smstr5
Sequence
MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEPRPDKSGRPQTTLPTRSCEANGLMQTSRL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Somatostatin receptor
Function
Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
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Uniprot ID
Primary ID:
O08858

Secondarily ID:
A6H6N8
O08998
Q3UZM7
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0072332
 Compound Info 
1-[2-[[5-cyclopropyl-4-(4-fluorophenyl)-2-propan-2-yloxyphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C31H38FN3O4
  1
1
IC50 = 3.9 nM
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CP0207041
 Compound Info 
1-[2-[[5-cyclopropyl-2-ethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C30H36FN3O4
  1
1
IC50 = 4.3 nM
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CP0085871
 Compound Info 
1-[2-[[3-ethoxy-4-(4-fluorophenyl)-5-methylphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C28H34FN3O4
  1
1
IC50 = 7.3 nM
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CP0517967
 Compound Info 
1-[2-[[5-cyclopropyl-4-(4-fluorophenyl)-2-methoxyphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C29H34FN3O4
  1
1
IC50 = 7.6 nM
 Bioactivity Info 
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CP0116714
 Compound Info 
1-[2-[[3-cyclopropyl-5-ethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C30H36FN3O4
  1
1
IC50 = 7.8 nM
 Bioactivity Info 
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CP0520082
 Compound Info 
1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C29H36FN3O5
  1
1
IC50 = 16 nM
 Bioactivity Info 
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CP0460414
 Compound Info 
1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-ethylpiperidine-4-carboxylic acid
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C30H38FN3O5
  1
1
IC50 = 19 nM
 Bioactivity Info 
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CP0561817
 Compound Info 
6-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]pyridine-3-carboxylic acid
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C28H28FN3O5
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0389778
 Compound Info 
4-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-3-methylbenzoic acid
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C30H31FN2O5
  1
1
IC50 = 21 nM
 Bioactivity Info 
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CP0493214
 Compound Info 
1-[2-[[3-ethoxy-5-ethyl-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C29H36FN3O4
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0236074
 Compound Info 
1-[2-[[3-chloro-5-cyclopropyl-2-ethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C30H35ClFN3O4
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0365008
 Compound Info 
1-[2-[[3-chloro-5-cyclopropyl-4-(4-fluorophenyl)-2-methoxyphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C29H33ClFN3O4
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0408223
 Compound Info 
1-[2-[[5-cyclopropyl-2-ethyl-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C30H36FN3O3
  1
1
IC50 = 29 nM
 Bioactivity Info 
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CP0465677
 Compound Info 
3-chloro-4-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzoic acid
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C29H28ClFN2O5
  1
1
IC50 = 31 nM
 Bioactivity Info 
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CP0529623
 Compound Info 
4-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzoic acid
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C29H29FN2O5
  1
1
IC50 = 33 nM
 Bioactivity Info 
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CP0079035
 Compound Info 
1-[2-[[5-cyclopropyl-2-ethoxy-4-(4-fluorophenyl)-3-methylphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C31H38FN3O4
  1
1
IC50 = 37 nM
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CP0546703
 Compound Info 
CHEMBL4072189
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C29H35FN2O5
  1
1
IC50 = 38 nM
 Bioactivity Info 
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CP0389777
 Compound Info 
1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]pyrrolidine-3-carboxylic acid;hydrochloride
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C27H33ClFN3O5
  1
1
IC50 = 48 nM
 Bioactivity Info 
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CP0274343
 Compound Info 
1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]piperidine-4-carboxylic acid
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C28H34FN3O5
  1
1
IC50 = 57 nM
 Bioactivity Info 
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CP0323968
 Compound Info 
1-[2-[[3-ethoxy-4-(4-fluorophenyl)-5-methoxyphenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C28H34FN3O5
  1
1
IC50 = 62 nM
 Bioactivity Info 
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CP0864095
 Compound Info 
(4-(2-((2,6-Diethoxy-4'-fluorobiphenyl-4-yl)methyl)-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl)phenyl)acetic acid hydrochloride
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C30H32ClFN2O5
  1
1
IC50 = 74 nM
 Bioactivity Info 
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CP0472685
 Compound Info 
1-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-fluoropiperidine-4-carboxylic acid
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C28H33F2N3O5
  1
1
IC50 = 78 nM
 Bioactivity Info 
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CP0411749
 Compound Info 
1-[2-[[2-cyclopropyl-5-ethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]-4-methylpiperidine-4-carboxylic acid
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C30H36FN3O4
  1
1
IC50 = 85 nM
 Bioactivity Info 
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CP0884345
 Compound Info 
1-(2-((2,6-Diethoxy-4'-fluorobiphenyl-4-yl)methyl)-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl)azetidine-3-carboxylic acid hydrochloride
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C26H31ClFN3O5
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0410576
 Compound Info 
4-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzamide
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C29H30FN3O4
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0390087
 Compound Info 
4-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]cyclohexane-1-carboxylic acid
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C29H35FN2O5
  1
1
IC50 = 210 nM
 Bioactivity Info 
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CP0520914
 Compound Info 
3-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]propanoic acid
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C25H29FN2O5
  1
1
IC50 = 220 nM
 Bioactivity Info 
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CP0396535
 Compound Info 
3-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzoic acid
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C29H29FN2O5
  1
1
IC50 = 260 nM
 Bioactivity Info 
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CP0483118
 Compound Info 
[4-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]phenyl]methanol
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C29H31FN2O4
  1
1
IC50 = 430 nM
 Bioactivity Info 
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CP0390090
 Compound Info 
2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-7-phenyl-5-oxa-2,6-diazaspiro[3.4]oct-6-ene
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C28H29FN2O3
  1
1
IC50 = 980 nM
 Bioactivity Info 
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CP0478370
 Compound Info 
4-[2-[1-[3,5-diethoxy-4-(4-fluorophenyl)phenyl]ethyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzoic acid
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C30H31FN2O5
  1
1
IC50 = 2000 nM
 Bioactivity Info 
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CP0076698
 Compound Info 
(1R,3R)-1-(oxan-4-yl)-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
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C25H26N4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0390088
 Compound Info 
4-[2-[3,5-diethoxy-4-(4-fluorophenyl)benzoyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzoic acid
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C29H27FN2O6
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0495640
 Compound Info 
2-[2-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]benzoic acid
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C29H29FN2O5
  1
1
IC50 > 10000 nM
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Cell Line ID: CL000026 , CHO-K1
 Cell Line Info