General Information of the Compound
Compound ID
CP0388069
Compound Name
(S)-(4-{2-[(5-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-ethyl}-piperazin-1-yl)-(1H-indol-5-yl)-methanone
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Structure
Formula
C28H36N4O2
Molecular Weight
460.622
Canonical SMILES
CCCN(CCN1CCN(CC1)C(=O)c1ccc2[nH]ccc2c1)[C@H]1CCc2c(O)cccc2C1
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InChI
InChI=1S/C28H36N4O2/c1-2-12-31(24-7-8-25-21(20-24)4-3-5-27(25)33)16-13-30-14-17-32(18-15-30)28(34)23-6-9-26-22(19-23)10-11-29-26/h3-6,9-11,19,24,29,33H,2,7-8,12-18,20H2,1H3/t24-/m0/s1
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InChIKey
HMYBAZWTOQSPCY-DEOSSOPVSA-N
Physicochemical Property
logP
3.9008
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
62.81
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45273211
ChEMBL ID
CHEMBL556269
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 41.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 157 nM
   TI
   LI
   LO
   TS
Protein ID: PT01366, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2.27 nM
   TI
   LI
   LO
   TS