General Information of the Compound
Compound ID
CP0386773
Compound Name
4-[2-(methylsulfonylcarbamoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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Structure
Formula
C31H35N3O8S
Molecular Weight
609.701
Canonical SMILES
CS(=O)(=O)NC(=O)C1CN(CCCC(O)=O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1
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InChI
InChI=1S/C31H35N3O8S/c1-43(39,40)33-31(38)27-21-34(19-8-14-28(35)36)26-13-7-12-25(29(26)42-27)32-30(37)23-15-17-24(18-16-23)41-20-6-5-11-22-9-3-2-4-10-22/h2-4,7,9-10,12-13,15-18,27H,5-6,8,11,14,19-21H2,1H3,(H,32,37)(H,33,38)(H,35,36)
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InChIKey
XFDWMOIFWMJDPH-UHFFFAOYSA-N
Physicochemical Property
logP
3.8486
Rotatable Bonds
14
Heavy Atom Count
43
Polar Areas
151.34
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11227280
SID: 16310561
ChEMBL ID
CHEMBL3401690
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01800, Cysteinyl leukotriene receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
Protein ID: PT03053, Cysteinyl leukotriene receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS