General Information of the Protein
Protein ID
PT03053
Protein Name
Cysteinyl leukotriene receptor 2
Secondarily
Protein Name
G-protein coupled receptor GPCR21
G-protein coupled receptor HG57
HPN321
Gene Name
CYSLTR2
Secondarily
Gene Name
CYSLT2
CYSLT2R
PSEC0146
Sequence
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Leukotriene receptor
Function
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
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Uniprot ID
Primary ID:
Q9NS75

Secondarily ID:
Q9HCQ2
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Ensembl ID
ENSG00000152207
HGNC ID
HGNC:18274
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0400409
 Compound Info 
4-(3-carboxypropyl)-8-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C31H33NO7
  1
1
IC50 = 0.31 nM
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CP0524590
 Compound Info 
4-[8-[[4-(4-phenylbutoxy)benzoyl]amino]-2-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C30H32N6O5
  1
1
IC50 = 0.49 nM
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CP0481627
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(5-phenylpentoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C31H34N2O7
  1
1
IC50 = 0.62 nM
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CP0379304
 Compound Info 
(2S)-4-(3-carboxypropyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H32N2O7
  1
1
IC50 = 0.87 nM
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CP0408242
 Compound Info 
4-[1-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]butanoic acid
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C34H34ClNO5
  1
1
IC50 = 0.88 nM
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CP0448955
 Compound Info 
2-[1-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]acetic acid
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C32H30ClNO5
  1
1
IC50 = 0.89 nM
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CP0382282
 Compound Info 
4-[1-(carboxymethyl)-2-methyl-7-[(E)-2-[4-[4-(2,3,6-trifluorophenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H32F3NO5
  1
1
IC50 = 1 nM
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CP0382284
 Compound Info 
4-[1-(carboxymethyl)-2-methyl-7-[(E)-2-[4-[4-(2,3,4,5-tetrafluorophenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H31F4NO5
  1
1
IC50 = 1.5 nM
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CP0487602
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(2,3,6-trifluorophenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C32H30F3NO5
  1
1
IC50 = 2.1 nM
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CP0411554
 Compound Info 
4-[1-(carboxymethyl)-2-methyl-7-[(E)-2-[4-[4-(2,3,4,6-tetrafluorophenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H31F4NO5
  1
1
IC50 = 2.2 nM
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CP0379267
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H32N2O7
  2
1
IC50 = 2.3 nM
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2
IC50 = 2.5 nM
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CP0379269
 Compound Info 
4-[8-[(E)-2-[4-(4-phenylbutoxy)phenyl]ethenyl]-2-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C31H33N5O4
  1
1
IC50 = 3.4 nM
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CP0494801
 Compound Info 
4-[1-(3-carboxypropyl)-2-methyl-7-[2-[4-[4-(2,3,4,6-tetrafluorophenyl)butoxy]phenyl]ethynyl]indol-3-yl]butanoic acid
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C35H33F4NO5
  1
1
IC50 = 3.6 nM
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CP0566585
 Compound Info 
4-[1-(carboxymethyl)-2-methyl-7-[(E)-2-[4-[4-(2,3,5,6-tetrafluorophenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H31F4NO5
  1
1
IC50 = 3.7 nM
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CP0379718
 Compound Info 
3-[(3-carboxycyclohexyl)carbamoyl]-4-[3-[4-(4-cyclohexyloxybutoxy)phenyl]propoxy]benzoic acid
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C34H45NO8
  2
1
IC50 = 3.8 nM
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2
IC50 = 38 nM
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CP0484535
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H34ClNO5
  1
1
IC50 = 4.6 nM
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CP0428421
 Compound Info 
4-[1-(carboxymethyl)-2-methyl-7-[(E)-2-[4-(4-phenylbutoxy)phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H35NO5
  1
1
IC50 = 4.7 nM
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CP0418315
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethenyl]-2-methylindol-3-yl]butanoic acid
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C34H36ClNO5
  1
1
IC50 = 5.1 nM
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CP0381577
 Compound Info 
4-[1-(3-carboxypropyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]butanoic acid
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C36H38ClNO5
  1
1
IC50 = 5.5 nM
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CP0429311
 Compound Info 
4-[2-(benzenesulfonylcarbamoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C36H37N3O8S
  1
1
IC50 = 5.7 nM
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CP0529629
 Compound Info 
4-(3-carboxypropyl)-8-[(E)-2-[4-(4-phenylbutoxy)phenyl]ethenyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C31H33NO6
  1
1
IC50 = 5.7 nM
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CP0382287
 Compound Info 
3-[1-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]propanoic acid
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C33H32ClNO5
  1
1
IC50 = 5.7 nM
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CP0408240
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]indol-3-yl]butanoic acid
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C32H33NO6
  1
1
IC50 = 6 nM
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CP0408236
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl]ethenyl]-2-methylindol-3-yl]butanoic acid
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C34H36FNO5
  1
1
IC50 = 7.2 nM
 Bioactivity Info 
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CP0380609
 Compound Info 
4-[1-(3-carboxypropyl)-7-[2-[4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]butanoic acid
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C36H38FNO5
  1
1
IC50 = 8.8 nM
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CP0456062
 Compound Info 
4-[1-(3-carboxypropyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-4-fluoro-2-methylindol-3-yl]butanoic acid
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C36H37ClFNO5
  1
1
IC50 = 12 nM
 Bioactivity Info 
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CP0432238
 Compound Info 
4-[1-(3-carboxypropyl)-4-fluoro-2-methyl-7-[2-[4-[4-(2,3,4,6-tetrafluorophenyl)butoxy]phenyl]ethynyl]indol-3-yl]butanoic acid
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C35H32F5NO5
  1
1
IC50 = 13 nM
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CP0484534
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C33H34FNO5
  1
1
IC50 = 14 nM
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CP0418562
 Compound Info 
4-[8-[2-[4-(4-phenylbutoxy)phenyl]ethyl]-2-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C31H35N5O4
  1
1
IC50 = 15 nM
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CP0382290
 Compound Info 
4-[3-(2-carboxyethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]butanoic acid
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C35H36ClNO5
  1
1
IC50 = 15 nM
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CP0484536
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(2-methoxyphenyl)butoxy]phenyl]ethenyl]-2-methylindol-3-yl]butanoic acid
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C34H37NO6
  1
1
IC50 = 15 nM
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CP0481625
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(3-phenoxypropoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C29H30N2O8
  1
1
IC50 = 16 nM
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CP0386772
 Compound Info 
4-(3-carboxypropyl)-8-[2-[4-(4-phenylbutoxy)phenyl]ethyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C31H35NO6
  1
1
IC50 = 16 nM
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CP0386773
 Compound Info 
4-[2-(methylsulfonylcarbamoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C31H35N3O8S
  1
1
IC50 = 16 nM
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CP0553496
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(4-phenoxybutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H32N2O8
  1
1
IC50 = 17 nM
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CP0448956
 Compound Info 
4-[1-(2-carboxyethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]butanoic acid
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C35H36ClNO5
  1
1
IC50 = 22 nM
 Bioactivity Info 
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CP0428430
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-[4-(3-chlorophenyl)butoxy]phenyl]ethenyl]indol-3-yl]butanoic acid
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C32H32ClNO5
  1
1
IC50 = 23 nM
 Bioactivity Info 
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CP0408239
 Compound Info 
4-[3-(carboxymethyl)-4-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]indol-1-yl]butanoic acid
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C32H33NO6
  2
1
IC50 = 25 nM
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2
IC50 = 27 nM
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CP0382286
 Compound Info 
4-[1-(carboxymethyl)-7-[(E)-2-[4-(4-phenylbutoxy)phenyl]ethenyl]indol-3-yl]butanoic acid
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C32H33NO5
  1
1
IC50 = 25 nM
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CP0427949
 Compound Info 
4-[1-(3-carboxypropyl)-4-fluoro-7-[2-[4-[4-(3-fluoro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]butanoic acid
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C36H37F2NO5
  1
1
IC50 = 25 nM
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CP0524589
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(4-phenylbutoxy)phenyl]methoxy]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H33NO7
  1
1
IC50 = 30 nM
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CP0382291
 Compound Info 
5-[3-(3-carboxypropyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]pentanoic acid
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C37H40ClNO5
  1
1
IC50 = 30 nM
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CP0456063
 Compound Info 
4-[1-(3-carboxypropyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-5-fluoro-2-methylindol-3-yl]butanoic acid
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C36H37ClFNO5
  1
1
IC50 = 31 nM
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CP0408238
 Compound Info 
4-[1-(3-carboxypropyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-6-fluoro-2-methylindol-3-yl]butanoic acid
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C36H37ClFNO5
  1
1
IC50 = 48 nM
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CP0379714
 Compound Info 
3-[(3-carboxycyclohexyl)carbamoyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]benzoic acid
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C34H39NO8
  1
1
IC50 = 53 nM
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CP0481626
 Compound Info 
(2R)-4-(3-carboxypropyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H32N2O7
  1
1
IC50 = 55 nM
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CP0484537
 Compound Info 
4-[3-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]butanoic acid
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C34H34ClNO5
  1
1
IC50 = 55 nM
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CP0448958
 Compound Info 
5-[3-(2-carboxyethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]pentanoic acid
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C36H38ClNO5
  1
1
IC50 = 60 nM
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CP0498608
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(3-phenylpropoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C29H30N2O7
  1
1
IC50 = 68 nM
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CP0384755
 Compound Info 
3-(3-carboxypropoxy)-8-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]quinoxaline-2-carboxylic acid
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C31H30N2O7
  1
1
IC50 = 75 nM
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CP0531079
 Compound Info 
3-[1-(2-carboxyethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-3-yl]propanoic acid
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C34H34ClNO5
  1
1
IC50 = 78 nM
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CP0382289
 Compound Info 
3-[3-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]propanoic acid
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C33H32ClNO5
  1
1
IC50 = 96 nM
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CP0494291
 Compound Info 
4-(4-carboxybutyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C31H34N2O7
  1
1
IC50 = 170 nM
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CP0533704
 Compound Info 
5-[3-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]pentanoic acid
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C35H36ClNO5
  1
1
IC50 = 248 nM
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CP0551481
 Compound Info 
4-(5-carboxypentyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C32H36N2O7
  1
1
IC50 = 290 nM
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CP0508488
 Compound Info 
4-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxynonadeca-6,8,10,13-tetraen-5-yl]sulfanylbenzoic acid
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C27H36O5S
  1
1
IC50 = 300 nM
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CP0400410
 Compound Info 
1-(3-carboxypropyl)-4-oxo-5-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]quinoline-3-carboxylic acid
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C32H31NO7
  1
1
IC50 = 370 nM
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CP0379268
 Compound Info 
4-[2-(hydroxymethyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C30H34N2O6
  1
1
IC50 = 410 nM
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CP0455907
 Compound Info 
4-(3-carboxypropanoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H30N2O8
  1
1
IC50 = 890 nM
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CP0511154
 Compound Info 
4-(5-carboxypentanoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C32H34N2O8
  1
1
IC50 = 890 nM
 Bioactivity Info 
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CP0379712
 Compound Info 
4-(3-carboxypropyl)-8-[[4-(2-phenoxyethoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C28H28N2O8
  1
1
IC50 = 1500 nM
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CP0455908
 Compound Info 
4-(4-carboxybutanoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C31H32N2O8
  1
1
IC50 = 1800 nM
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CP0455909
 Compound Info 
4-acetyl-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C28H28N2O6
  1
1
IC50 = 3600 nM
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CP0379709
 Compound Info 
4-butanoyl-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C30H32N2O6
  1
1
IC50 = 3700 nM
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CP0418561
 Compound Info 
4-[8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acid
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C29H32N2O5
  1
1
IC50 = 4300 nM
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CP0489186
 Compound Info 
8-[[4-(4-phenylbutoxy)benzoyl]amino]-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid
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C26H26N2O5
  1
1
IC50 = 4600 nM
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CP0379707
 Compound Info 
8-[[4-(4-phenylbutoxy)benzoyl]amino]-4-propanoyl-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid
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C29H30N2O6
  1
1
IC50 = 5200 nM
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CP0551497
 Compound Info 
(Z)-2-cyano-N-[2-(4-cyanobenzoyl)-5-[(E)-4-(diethylamino)-4-oxobut-2-en-2-yl]-1-benzofuran-3-yl]-3-hydroxybut-2-enamide
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C29H26N4O5
  1
1
IC50 = 7700 nM
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CP0380350
 Compound Info 
3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-7-methoxy-1H-indole-2-carboxylic acid
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C30H22ClN3O4
  1
1
IC50 = 15000 nM
 Bioactivity Info 
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CP0380616
 Compound Info 
3-[[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]carbamoyl]-1H-indole-2-carboxylic acid
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C27H18ClN3O3
  1
1
IC50 = 23000 nM
 Bioactivity Info 
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CP0380618
 Compound Info 
CHEBI:6993
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C35H35ClNNaO3S
  1
1
IC50 = 27000 nM
 Bioactivity Info 
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CP0380375
 Compound Info 
4-chloro-3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C29H19Cl2N3O3
  1
1
IC50 = 36000 nM
 Bioactivity Info 
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CP0959286
 Compound Info 
Pranlukast hemihydrate
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C27H25N5O5
  1
1
IC50 = 43000 nM
 Bioactivity Info 
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CP0399551
 Compound Info 
3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-5-fluoro-1H-indole-2-carboxylic acid
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C29H19ClFN3O3
  1
1
IC50 = 46000 nM
 Bioactivity Info 
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CP0508763
 Compound Info 
3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-5-methoxy-1H-indole-2-carboxylic acid
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C30H22ClN3O4
  1
1
IC50 = 46000 nM
 Bioactivity Info 
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CP0531289
 Compound Info 
3-[3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxopropyl]-1H-indole-2-carboxylic acid
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C29H22ClN3O3
  1
1
IC50 = 50000 nM
 Bioactivity Info 
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CP0045344
 Compound Info 
4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide
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C31H33N3O6S
  1
1
IC50 = 58000 nM
 Bioactivity Info 
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CP0399550
 Compound Info 
3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C29H20ClN3O3
  1
1
IC50 = 58000 nM
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CP0399347
 Compound Info 
3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-4,6-difluoro-1H-indole-2-carboxylic acid
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C29H18ClF2N3O3
  1
1
IC50 = 76000 nM
 Bioactivity Info 
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CP0390349
 Compound Info 
6-chloro-3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C29H19Cl2N3O3
  1
1
IC50 = 87000 nM
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CP0380376
 Compound Info 
4,6-dichloro-3-[(E)-3-cyclohexyloxy-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C18H17Cl2NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0380377
 Compound Info 
4,6-dichloro-3-[(E)-3-oxo-3-(4-phenylbutoxy)prop-1-enyl]-1H-indole-2-carboxylic acid
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C22H19Cl2NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0380619
 Compound Info 
4,6-dichloro-3-[(E)-3-[[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]methoxy]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C30H19Cl3N2O4
  1
1
IC50 > 100000 nM
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CP0399548
 Compound Info 
4,6-dichloro-3-[(E)-3-oxo-3-phenoxyprop-1-enyl]-1H-indole-2-carboxylic acid
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C18H11Cl2NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0407630
 Compound Info 
4,6-dichloro-3-[(E)-3-oxo-3-(3-phenylpropoxy)prop-1-enyl]-1H-indole-2-carboxylic acid
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C21H17Cl2NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0414693
 Compound Info 
4,6-dichloro-3-[(E)-3-(4-cyanobutoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C17H14Cl2N2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0414695
 Compound Info 
7-chloro-3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C29H19Cl2N3O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0429281
 Compound Info 
4,6-dichloro-3-[(E)-3-oxo-3-phenylmethoxyprop-1-enyl]-1H-indole-2-carboxylic acid
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C19H13Cl2NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0447690
 Compound Info 
4,6-dichloro-3-[(E)-3-oxo-3-pentoxyprop-1-enyl]-1H-indole-2-carboxylic acid
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C17H17Cl2NO4
  1
1
IC50 > 100000 nM
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CP0447691
 Compound Info 
[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]methyl (E)-3-(4,6-dichloro-1H-indol-3-yl)prop-2-enoate
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C29H19Cl3N2O2
  1
1
IC50 > 100000 nM
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CP0451909
 Compound Info 
4,6-dichloro-3-[(E)-3-(4-methylpentoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C18H19Cl2NO4
  1
1
IC50 > 100000 nM
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CP0451911
 Compound Info 
4,6-dichloro-3-[(E)-3-(cyclohexylmethoxy)-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C19H19Cl2NO4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0458738
 Compound Info 
4,6-dichloro-3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C29H18Cl3N3O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0459655
 Compound Info 
3-[(E)-3-[[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]methoxy]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C30H21ClN2O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0469615
 Compound Info 
3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-6-methoxy-1H-indole-2-carboxylic acid
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C30H22ClN3O4
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0531290
 Compound Info 
5-chloro-3-[(E)-3-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]anilino]-3-oxoprop-1-enyl]-1H-indole-2-carboxylic acid
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C29H19Cl2N3O3
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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CP0538956
 Compound Info 
4,6-dichloro-3-[(E)-3-oxo-3-(2-phenylethoxy)prop-1-enyl]-1H-indole-2-carboxylic acid
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C20H15Cl2NO4
  1
1
IC50 > 100000 nM
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Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Leukotriene CysLT2 receptor (CYSLTR2) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Asthma [ICD-11: CA23]
Discontinued Drug(s) 2 Discontinued Drugs  2
1 FPL-55712
 Drug Info 
Terminated
Asthma
2 ICI-198615
 Drug Info 
Terminated
Asthma