General Information of the Compound
Compound ID
CP0384367
Compound Name
2-[4-(5-chloropyridin-2-yl)piperazin-1-yl]-N-(3-ethylphenyl)acetamide
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Structure
Formula
C19H23ClN4O
Molecular Weight
358.873
Canonical SMILES
CCc1cccc(NC(=O)CN2CCN(CC2)c2ccc(Cl)cn2)c1
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InChI
InChI=1S/C19H23ClN4O/c1-2-15-4-3-5-17(12-15)22-19(25)14-23-8-10-24(11-9-23)18-7-6-16(20)13-21-18/h3-7,12-13H,2,8-11,14H2,1H3,(H,22,25)
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InChIKey
MJNKHSYDQLOGOJ-UHFFFAOYSA-N
Physicochemical Property
logP
3.0581
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
48.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155516494
ChEMBL ID
CHEMBL4443848
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 46795 nM
   TI
   LI
   LO
   TS
2
IC50 = 70703 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 46260 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 50000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01161, D(4) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 7059 nM
   TI
   LI
   LO
   TS
2
IC50 = 10449 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 172.2 nM
   TI
   LI
   LO
   TS