General Information of the Compound
Compound ID
CP0352008
Compound Name
4-methyl-8-[3-[(2R)-2-methyl-4-(2-methylquinolin-5-yl)piperazin-1-yl]propyl]-1,4-benzoxazin-3-one
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Structure
Formula
C27H32N4O2
Molecular Weight
444.579
Canonical SMILES
C[C@@H]1CN(CCN1CCCc1cccc2N(C)C(=O)COc12)c1cccc2nc(C)ccc12
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InChI
InChI=1S/C27H32N4O2/c1-19-12-13-22-23(28-19)9-5-10-24(22)31-16-15-30(20(2)17-31)14-6-8-21-7-4-11-25-27(21)33-18-26(32)29(25)3/h4-5,7,9-13,20H,6,8,14-18H2,1-3H3/t20-/m1/s1
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InChIKey
GIQHYUIXZZZJQF-HXUWFJFHSA-N
Physicochemical Property
logP
4.04172
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
48.91
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44592333
ChEMBL ID
CHEMBL469376
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6309.57 nM
   TI
   LI
   LO
   TS
Protein ID: PT00871, Sodium-dependent serotonin transporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000009 LLC-PK1 Sus scrofa (Pig)  1
1
Ki = 0.5012 nM
   TI
   LI
   LO
   TS