General Information of the Compound
Compound ID
CP0056218
Compound Name
(Z)-but-2-enedioic acid;[4-(morpholin-4-ylmethyl)phenyl]-(4-propan-2-ylpiperazin-1-yl)methanone
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Structure
Formula
C19H29N3O2
Molecular Weight
331.46
Canonical SMILES
CC(C)N1CCN(CC1)C(=O)c1ccc(CN2CCOCC2)cc1
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InChI
InChI=1S/C19H29N3O2.C4H4O4/c1-16(2)21-7-9-22(10-8-21)19(23)18-5-3-17(4-6-18)15-20-11-13-24-14-12-20;5-3(6)1-2-4(7)8/h3-6,16H,7-15H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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InChIKey
PWDBREUBRYUEGC-BTJKTKAUSA-N
Physicochemical Property
logP
1.685
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
36.02
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122178129
ChEMBL ID
CHEMBL3577955
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000074 SK-N-MC Homo sapiens (Human)  1
1
Ki = 2.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS