General Information of the Compound
Compound ID
CP0050791
Compound Name
(2S)-2-amino-3-(phosphonooxy)propanoic acid
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Synonyms
LSOP
(+)-L-Serine dihydrogen phosphate (ester)
3-O-Phosphoserine
3-phosphoserine
407-41-0
Dexfosfoserine
Dexfosfoserine [INN]
Fosforina
H-Ser(PO)-OH
H-Ser(PO3H2)-OH
L-2-amino-3-hydroxypropanoic acid 3-phosphate
L-3-Phosphoserine
L-O-Phosphoserine
L-O-Serine phosphate
L-Phosphoserine
L-SOP
L-Serine O-phosphate
L-Serinephosphoric acid
L-Seryl phosphate
L-serine-O-phosphate
O-Phosphoserine
O-phospho-L-serine
O-phosphono-L-serine
PHOSPHONOSERINE
Phosphatidalserine
Phosphonoserine
Phosphoserine
UNII-VI4F0K069V
phosphoserine
serine, O-phosphono-
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Structure
Formula
C3H8NO6P
Molecular Weight
185.072
Canonical SMILES
N[C@@H](COP(O)(O)=O)C(O)=O
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InChI
InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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InChIKey
BZQFBWGGLXLEPQ-REOHCLBHSA-N
CAS
407-41-0
Physicochemical Property
logP
-1.4924
Rotatable Bonds
4
Heavy Atom Count
11
Polar Areas
130.08
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
11

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68841
SID: 15340053
ChEMBL ID
CHEMBL284377
DrugBank ID
DB04522
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02446, Metabotropic glutamate receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 < 100000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( L-serine-O-phosphate )
Drug Name L-serine-O-phosphate
Target(s)
Metabotropic glutamate receptor 8 (mGluR8)
Agonist
Metabotropic glutamate receptor 7 (mGluR7)
Agonist
Metabotropic glutamate receptor 4 (mGluR4)
Agonist
Metabotropic glutamate receptor 6 (mGluR6)
Agonist
Phosphoinositide dependent protein kinase-1 (PDPK1)
Inhibitor
Glycogen phosphorylase muscle form (GP)
Inhibitor
Rhodopsin (RHO)
Inhibitor
Protein kinase C theta (PRKCQ)
Inhibitor