General Information of the Protein
Protein ID
PT02194
Protein Name
Glycogen phosphorylase, muscle form
Secondarily
Protein Name
Myophosphorylase
Gene Name
PYGM
Sequence
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
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Uniprot ID
Primary ID:
P11217

Secondarily ID:
A0AVK1
A6NDY6
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Ensembl ID
ENSG00000068976
HGNC ID
HGNC:9726
Clinical Information about the Protein
Target 1 ( Glycogen phosphorylase muscle form (GP) )
Target Type Patented-recorded Target
Disease 1 Target-related Disease  1
1 Metabolic syndrome x [ICD-11: 5C50-5D2Z]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 URSOLIC ACID
 Drug Info 
Phase 2
Metabolic syndrome x
Target 2 ( Myophosphorylase (PYGM) )
Target Type Discontinued Target
Disease 1 Target-related Disease  1
1 Acute myeloid leukaemia [ICD-11: 2A60]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Flavopiridol
 Drug Info 
Phase 2
Acute myeloid leukaemia