General Information of the Compound
| Compound ID |
CP0048641
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| Compound Name |
(2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide
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| Synonyms |
(2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide
(2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic acid
(2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl)carbamoyl)-2-hydroxy-5-methylhexanohydroxamic acid
(2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide
BB 2516
BB-2516
Marimastat
Marimastat (USAN/INN)
Marimastat [USAN]
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| Structure |
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| Formula |
C15H29N3O5
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| Molecular Weight |
331.413
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| Canonical SMILES |
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
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| InChI |
InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
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| InChIKey |
OCSMOTCMPXTDND-OUAUKWLOSA-N
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| CAS |
154039-60-8
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Clinical Information about the Compound
Drug 1 ( Marimastat )
| Drug Name | Marimastat | ||
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| Company | British Biotech plc; Schering-Plough | ||
| Indication | |||
| Target(s) |
Matrix metalloproteinase-7 (MMP-7)
Inhibitor
Matrix metalloproteinase-1 (MMP-1)
Inhibitor
Matrix metalloproteinase-2 (MMP-2)
Inhibitor
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