General Information of the Protein
| Protein ID |
PT00950
|
||||
|---|---|---|---|---|---|
| Protein Name |
Matrilysin
|
||||
| Secondarily Protein Name |
Matrin
Matrix metalloproteinase-7
Pump-1 protease
Uterine metalloproteinase
|
||||
| Gene Name |
MMP7
|
||||
| Secondarily Gene Name |
MPSL1
PUMP1
|
||||
| Sequence |
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
Show/Hide
|
||||
| Organism |
Homo sapiens, Human
|
||||
| Protein Classification |
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAM clan
>
Metallo protease M10A subfamily
|
||||
| Function |
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Show/Hide
|
||||
| Uniprot ID |
Show/Hide
|
||||
| Ensembl ID | |||||
| HGNC ID | |||||
| Subcellular Location |
Secreted
Extracellular space
Extracellular matrix
|
||||
Map of Molecular Bioactivity Related to the Protein
|
Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
|
|---|
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Biochemical Assays
Clinical Information about the Protein
Target 1 ( Matrix metalloproteinase-7 (MMP-7) )
| Target Type | Successful Target | ||||
|---|---|---|---|---|---|
| Disease | 3 Target-related Diseases | 3 | |||
| 1 | Lung cancer [ICD-11: 2C25.0] | ||||
| 2 | Pancreatic cancer [ICD-11: 2C10] | ||||
| 3 | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | ||||
| Approved Drug(s) | 1 Approved Drug | 1 | |||
| 1 | Prinomastat | Approved | |||
| Clinical Trial Drug(s) | 1 Clinical Trial Drug | 1 | |||
| 1 | Marimastat | Phase 3 | |||
| Discontinued Drug(s) | 1 Discontinued Drug | 1 | |||
| 1 | BB-3644 | Terminated | |||