General Information of the Compound
| Compound ID |
CP0036977
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| Compound Name |
(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione
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| Synonyms |
(+)-Camptothecin
(+)-Camptothecine
(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(S)-(+)-Camptothecin
(S)-Camptothecin
20(S)-Camptothecin
20(S)-Camptothecine
21,22-Secocamptothecin-21-oic acid lactone
7689-03-4
CHEBI:27656
CHEMBL65
Campathecin
Camptothecin
Camptothecin derivat
Camptothecin, Camptotheca acuminata
Camptothecine
Camptothecine (8CI)
Camptothecine (S,+)
MLS000766223
NSC-94600
NSC94600
UNII-XT3Z54Z28A
VSJKWCGYPAHWDS-FQEVSTJZSA-N
XT3Z54Z28A
camptothecin
d-Camptothecin
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| Structure |
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| Formula |
C20H16N2O4
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| Molecular Weight |
348.358
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| Canonical SMILES |
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
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| InChI |
InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
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| InChIKey |
VSJKWCGYPAHWDS-FQEVSTJZSA-N
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| CAS |
7689-03-4
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05334, ATP-binding cassette sub-family C member 4
Protein ID: PT01170, DNA topoisomerase 1
Protein ID: PT06109, Geminin
Protein ID: PT00865, Serine/threonine-protein kinase Chk1
Protein ID: PT01065, Serine/threonine-protein kinase mTOR
Clinical Information about the Compound