General Information of the Compound
Compound ID
CP0036204
Compound Name
CAS_36322-90-4
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Synonyms
(3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1
(4-Hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazin-3-yl)-N-(2-pyridyl)carboxamide
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide
3-[hydroxy(pyridin-2-ylamino)methylidene]-2-methyl-3,4-dihydro-2H-1
4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide
4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid
4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid [German]
4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-N-pyridin-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
AK1015
Akten
Apo-Piroxicam
Artroxicam
Brexidol (TN)
Brexin (TN)
Bruxicam
CHF 1251
CP 16171
CP-16171
CP16171
Caliment
Erazon
Erazon (TN)
Exipan (TN)
Felden
Felden (TN)
Feldene
Feldene (TN)
Feldene Fast
Feldene Gel
Feldene, Roxam, Piroxicam
Feldoral (TN)
Flogobene
Geldene
Hotemin (TN)
Improntal
Larapam
Mobilis (TN)
P 5654
Pipoxicam
Pirkam
Piroflex
Piroftal
Pirox von ct (TN)
Piroxicam
Piroxicam (JP15/USP/INN)
Piroxicam [USAN:BAN:INN:JAN]
Piroxicam usp
Piroxicamum
Piroxicamum [INN-Latin]
Proponol (TN)
Pyroxycam
Reudene
Reumador (TN)
Riacen
Roxicam
Roxiden
Sasulen
Solocalm
Tracam (TN)
Veral (TN)
Vurdon (TN)
Zunden
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Structure
Formula
C15H13N3O4S
Molecular Weight
331.353
Canonical SMILES
CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O
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InChI
InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
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InChIKey
QYSPLQLAKJAUJT-UHFFFAOYSA-N
CAS
36322-90-4
Physicochemical Property
logP
1.581
Rotatable Bonds
2
Heavy Atom Count
23
Polar Areas
99.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 54676228
SID: 14924343
ChEMBL ID
CHEMBL527
DrugBank ID
DB00554
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02209, Organic anion transporter 3
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000090 Schneider 2
 Cell Line Info 
Drosophila melanogaster (Fruit fly)  1
1
Ki = 4880 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT04064, Solute carrier family 22 member 6
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 20500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CL000090 Schneider 2
 Cell Line Info 
Drosophila melanogaster (Fruit fly)  1
1
Ki = 19800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Piroxicam )
Drug Name Piroxicam
Company Pfizer Pharmaceuticals
Indication
Pain
Approved
Target(s)
Prostaglandin G/H synthase 1 (COX-1)
 Target Info 
Modulator