General Information of the Cell Line
Cell Line ID
CL000766
Cell Line Name
SAL1
Synonyms
SAL-1
SAL
Category
Cancer cell line
Organism
Homo sapiens (Human)
Disease
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01104, Insulin-like growth factor 1 receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0024739
 Compound Info 
4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydropyridin-2-one
   Show/Hide
C25H26ClN5O3
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
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   LO
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CP0384425
 Compound Info 
4-(2-(4-bromo-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C22H24BrN7O2
  1
1
IC50 = 144 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0440345
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C24H21ClN6O2
  1
1
IC50 = 190 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0251811
 Compound Info 
4-(2-(4-bromo-3-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26BrN7O2
  1
1
IC50 = 197 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0310698
 Compound Info 
4-(2-(5-chloro-1,2-dimethyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C24H28ClN7O2
  1
1
IC50 = 266 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0256834
 Compound Info 
4-(2-(5-bromo-1-ethyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C24H28BrN7O2
  1
1
IC50 = 284 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036963
 Compound Info 
4-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26ClN7O2
  1
1
IC50 = 292 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036967
 Compound Info 
4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H25Cl2N7O2
  1
1
IC50 = 306 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0095421
 Compound Info 
4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26ClN7O2
  1
1
IC50 = 336 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0063518
 Compound Info 
4-(2-(5-bromo-1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26BrN7O2
  1
1
IC50 = 343 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036968
 Compound Info 
4-(2-(1-isopropyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C25H31N7O2
  1
1
IC50 = 365 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0049842
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C24H21ClN6O2
  1
1
IC50 = 370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0256833
 Compound Info 
4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C22H24ClN7O2
  1
1
IC50 = 376 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036965
 Compound Info 
4-(2-(4-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H27N7O2
  1
1
IC50 = 397 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0370645
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-hydroxy-2-m-tolylethylamino)pyridin-2(1H)-one
   Show/Hide
C25H24N6O2
  1
1
IC50 = 420 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0251812
 Compound Info 
4-(2-(3-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H27N7O2
  1
1
IC50 = 422 nM
 Bioactivity Info 
   TI
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CP0287478
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-((R)-2-(3-chlorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C24H21ClN6O2
  1
1
IC50 = 440 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0063517
 Compound Info 
4-(2-(5-chloro-1-(2-fluoroethyl)-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C24H27ClFN7O2
  1
1
IC50 = 451 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0230778
 Compound Info 
4-(2-(5-chloro-1-ethyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C24H28ClN7O2
  1
1
IC50 = 469 nM
 Bioactivity Info 
   TI
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CP0198200
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-fluorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C24H21FN6O2
  1
1
IC50 = 470 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0332200
 Compound Info 
4-(2-(1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H27N7O2
  1
1
IC50 = 521 nM
 Bioactivity Info 
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CP0317551
 Compound Info 
ethyl 1-[2-[[3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)-2-oxo-1H-pyridin-4-yl]amino]ethyl]pyrazole-4-carboxylate
   Show/Hide
C25H29N7O4
  1
1
IC50 = 531 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0133153
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-chloro-4-methoxyphenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C25H23ClN6O3
  1
1
IC50 = 540 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0140808
 Compound Info 
4-(2-(5-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H27N7O2
  1
1
IC50 = 542 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0168314
 Compound Info 
4-(2-(1-ethyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C24H29N7O2
  1
1
IC50 = 583 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0340500
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-hydroxy-2-(4-methoxyphenyl)ethylamino)pyridin-2(1H)-one
   Show/Hide
C25H24N6O3
  1
1
IC50 = 610 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0074260
 Compound Info 
4-(2-(1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C22H25N7O2
  1
1
IC50 = 613 nM
 Bioactivity Info 
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CP0279399
 Compound Info 
4-(2-(5-chloro-1-(2-methoxyethyl)-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C25H30ClN7O3
  1
1
IC50 = 622 nM
 Bioactivity Info 
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CP0364387
 Compound Info 
4-(2-(4-bromo-3-(hydroxymethyl)-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26BrN7O3
  1
1
IC50 = 697 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0371441
 Compound Info 
4-(2-(4-bromo-5-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26BrN7O2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0095419
 Compound Info 
methyl 1-[2-[[3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)-2-oxo-1H-pyridin-4-yl]amino]ethyl]pyrazole-4-carboxylate
   Show/Hide
C24H27N7O4
  1
1
IC50 = 711 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0370644
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-hydroxy-2-p-tolylethylamino)pyridin-2(1H)-one
   Show/Hide
C25H24N6O2
  1
1
IC50 = 750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0133154
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-chloro-4-fluorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C24H20ClFN6O2
  1
1
IC50 = 760 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0364386
 Compound Info 
4-(2-(4-chloro-5-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26ClN7O2
  1
1
IC50 = 777 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0176602
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-hydroxy-2-(3-methoxyphenyl)ethylamino)pyridin-2(1H)-one
   Show/Hide
C25H24N6O3
  1
1
IC50 = 780 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0324275
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-hydroxy-2-(3-(trifluoromethyl)phenyl)ethylamino)pyridin-2(1H)-one
   Show/Hide
C25H21F3N6O2
  1
1
IC50 = 780 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0036964
 Compound Info 
4-(2-(4-bromo-5-(hydroxymethyl)-1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C23H26BrN7O3
  1
1
IC50 = 796 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0074261
 Compound Info 
1-(2-(3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)-2-oxo-1,2-dihydropyridin-4-ylamino)ethyl)-1H-pyrazole-4-carbonitrile
   Show/Hide
C23H24N8O2
  1
1
IC50 = 821 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0264523
 Compound Info 
4-(2-(5-chloro-1-isopropyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C25H30ClN7O2
  1
1
IC50 = 1140 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0284966
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3,4-dichlorophenyl)-2-hydroxyethylamino)pyridin-2(1H)-one
   Show/Hide
C24H20Cl2N6O2
  1
1
IC50 = 1270 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0036969
 Compound Info 
4-(2-(1-(2-methoxyethyl)-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C25H31N7O3
  1
1
IC50 = 1510 nM
 Bioactivity Info 
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   LI
   LO
   TS
CP0287476
 Compound Info 
3-(2-(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-2-oxo-1,2-dihydropyridin-4-ylamino)-1-hydroxyethyl)benzonitrile
   Show/Hide
C25H21N7O2
  1
1
IC50 = 1640 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0133141
 Compound Info 
3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-(3-bromophenyl)propylamino)pyridin-2(1H)-one
   Show/Hide
C25H23BrN6O
  1
1
IC50 = 1790 nM
 Bioactivity Info 
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   LO
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CP0264522
 Compound Info 
4-(2-(1-ethyl-5-ethynyl-1H-imidazol-4-yl)ethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
   Show/Hide
C26H29N7O2
  1
1
IC50 = 2034 nM
 Bioactivity Info 
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CP0307110
 Compound Info 
N-[3-[1-hydroxy-2-[[3-(6-imidazol-1-yl-4-methyl-1H-benzimidazol-2-yl)-2-oxo-1H-pyridin-4-yl]amino]ethyl]phenyl]methanesulfonamide
   Show/Hide
C25H25N7O4S
  1
1
IC50 = 3630 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT06120, Insulin-like growth factor 1 receptor
 Protein Info 
Protein family and CMB statistics Related to the Cell Line