Brief Information of the Cell Line and Protein
Cell Line ID: CL000870 , HEK-Blue Null1-v
Category Transformed cell line
Organism
Homo sapiens (Human)
Protein ID: PT03970 , Nucleotide-binding oligomerization domain-containing protein 2
Gene Name NOD2
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID Q9HC29
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000870  Protein ID: PT03970
 
Compound ID Compound Name Compound Formula
CP0396107
diethyl (2R)-2-[[(2S)-2-[[2-[[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]pentanedioate
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C26H37N3O9
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0380222
CHEBI:59414
   Show/Hide
C19H32N4O11
 1
1
EC50 = 92 nM
   TI
   LI
   LO
   TS
CP0396101
diethyl (2R)-2-[[(2S)-2-[[2-[[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanedioate
   Show/Hide
C30H37N3O9
 1
1
EC50 = 121 nM
   TI
   LI
   LO
   TS
CP0396106
diethyl (2R)-2-[[(2S)-2-[[2-[[(E)-3-(3,4-difluorophenyl)prop-2-enoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanedioate
   Show/Hide
C29H33F2N3O7
 1
1
EC50 = 172 nM
   TI
   LI
   LO
   TS
CP0519351
diethyl (2R)-2-[[(2S)-2-[[2-[[(E)-3-(3,4-difluorophenyl)prop-2-enoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]pentanedioate
   Show/Hide
C25H33F2N3O7
 1
1
EC50 = 172 nM
   TI
   LI
   LO
   TS
CP0396099
diethyl (2R)-2-[[(2S)-3-methyl-2-[[2-[[(E)-3-phenylprop-2-enoyl]amino]acetyl]amino]butanoyl]amino]pentanedioate
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C25H35N3O7
 1
1
EC50 = 223 nM
   TI
   LI
   LO
   TS
CP0437132
diethyl (2R)-2-[[(2S)-2-[[2-[[2-(3,4-difluorophenyl)cyclopropanecarbonyl]amino]acetyl]amino]-3-methylbutanoyl]amino]pentanedioate
   Show/Hide
C26H35F2N3O7
 1
1
EC50 = 247 nM
   TI
   LI
   LO
   TS
CP0396105
diethyl (2R)-2-[[(2S)-2-[[2-[[2-(3,4-difluorophenyl)cyclopropanecarbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanedioate
   Show/Hide
C30H35F2N3O7
 1
1
EC50 = 276 nM
   TI
   LI
   LO
   TS
CP0458472
diethyl (2R)-2-[[(2S)-3-phenyl-2-[[2-[[(E)-3-phenylprop-2-enoyl]amino]acetyl]amino]propanoyl]amino]pentanedioate
   Show/Hide
C29H35N3O7
 1
1
EC50 = 388 nM
   TI
   LI
   LO
   TS
CP0396102
diethyl (2R)-2-[[(2S)-3-phenyl-2-[[2-[[(1R,2R)-2-phenylcyclopropanecarbonyl]amino]acetyl]amino]propanoyl]amino]pentanedioate
   Show/Hide
C30H37N3O7
 1
1
EC50 = 472 nM
   TI
   LI
   LO
   TS
CP0396104
diethyl (2R)-2-[[(2S)-3-phenyl-2-[[2-[(6-phenyl-1H-indole-2-carbonyl)amino]acetyl]amino]propanoyl]amino]pentanedioate
   Show/Hide
C35H38N4O7
 1
1
EC50 = 777 nM
   TI
   LI
   LO
   TS
CP0396100
diethyl (2R)-2-[[(2S)-2-[[2-[[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]acetyl]amino]propanoyl]amino]pentanedioate
   Show/Hide
C24H33N3O9
 1
1
EC50 = 2790 nM
   TI
   LI
   LO
   TS
CP0424616
diethyl (2R)-2-[[(2S)-2-[[2-[(6-phenyl-1H-indole-2-carbonyl)amino]acetyl]amino]propanoyl]amino]pentanedioate
   Show/Hide
C29H34N4O7
 1
1
EC50 = 2880 nM
   TI
   LI
   LO
   TS
CP0457972
(2R)-2-[[(2S)-2-[[2-[[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]pentanedioic acid
   Show/Hide
C22H29N3O9
 1
1
EC50 = 6980 nM
   TI
   LI
   LO
   TS
CP0513593
N-[(3R)-7-[3-(dimethylamino)phenoxy]-3-[3-(4-fluoropiperidin-1-yl)-3-oxopropyl]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-8-yl]-2-[[4-(trifluoromethyl)phenyl]methoxy]acetamide
   Show/Hide
C35H37F4N5O6
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0393776
methyl 3-[(3S)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[[2-[[4-(trifluoromethyl)phenyl]methoxy]acetyl]amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C31H31F3N4O7
 1
1
IC50 = 590 nM
   TI
   LI
   LO
   TS
CP0393844
N-[(3R)-3-[3-(4,4-difluoropiperidin-1-yl)-3-oxopropyl]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-8-yl]-2-[[4-(trifluoromethyl)phenyl]methoxy]acetamide
   Show/Hide
C35H36F5N5O6
 1
1
IC50 = 810 nM
   TI
   LI
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   TS
CP0412931
methyl 3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[[2-[[4-(trifluoromethyl)phenyl]methoxy]acetyl]amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C31H31F3N4O7
 1
1
IC50 = 870 nM
   TI
   LI
   LO
   TS
CP0472375
2-[(4-chlorophenyl)methoxy]-N-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3-(3-oxo-3-piperidin-1-ylpropyl)-3,4-dihydro-1H-1,4-benzodiazepin-8-yl]acetamide
   Show/Hide
C34H38ClN5O6
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0393791
N-[(3S)-7-[3-(dimethylamino)phenoxy]-3-methyl-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-8-yl]-2-[[4-(trifluoromethyl)phenyl]methoxy]acetamide
   Show/Hide
C28H27F3N4O5
 1
1
IC50 = 940 nM
   TI
   LI
   LO
   TS
CP0393784
methyl 3-[(3R)-7-[4-chloro-3-(dimethylamino)phenoxy]-8-[[2-[(4-chlorophenyl)methoxy]acetyl]amino]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H30Cl2N4O7
 1
1
IC50 = 1020 nM
   TI
   LI
   LO
   TS
CP0405258
methyl 3-[(3R)-8-[[2-[(4-bromophenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31BrN4O7
 1
1
IC50 = 1190 nM
   TI
   LI
   LO
   TS
CP0405613
methyl 3-[(3R)-8-[[2-[(4-chlorophenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31ClN4O7
 1
1
IC50 = 1240 nM
   TI
   LI
   LO
   TS
CP0393795
N,N-dibutyl-3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
   Show/Hide
C37H47N5O6
 1
1
IC50 = 1320 nM
   TI
   LI
   LO
   TS
CP0393787
methyl 3-[(3R)-8-[[2-[(4-chlorophenyl)methoxy]acetyl]amino]-2,5-dioxo-7-(3-pyrrolidin-1-ylphenoxy)-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C32H33ClN4O7
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0393842
methyl 3-[(3R)-7-[3-(dimethylamino)phenoxy]-8-[[2-(naphthalen-2-ylmethoxy)acetyl]amino]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C34H34N4O7
 1
1
IC50 = 1580 nM
   TI
   LI
   LO
   TS
CP0394541
methyl 3-[(3R)-8-[[2-[(3,4-difluorophenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H30F2N4O7
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0393766
methyl 3-[(3R)-8-[[2-[(3-chlorophenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31ClN4O7
 1
1
IC50 = 2080 nM
   TI
   LI
   LO
   TS
CP0551689
N-tert-butyl-3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
   Show/Hide
C33H39N5O6
 1
1
IC50 = 2270 nM
   TI
   LI
   LO
   TS
CP0393840
methyl 3-[(3R)-8-[[2-[(3-bromophenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31BrN4O7
 1
1
IC50 = 2280 nM
   TI
   LI
   LO
   TS
CP0394543
methyl 3-[(3R)-8-[[2-[(4-tert-butylphenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C34H40N4O7
 1
1
IC50 = 2390 nM
   TI
   LI
   LO
   TS
CP0393772
methyl 3-[(3R)-8-[[2-[(4-cyanophenyl)methoxy]acetyl]amino]-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C31H31N5O7
 1
1
IC50 = 2510 nM
   TI
   LI
   LO
   TS
CP0470006
N-butyl-3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
   Show/Hide
C33H39N5O6
 1
1
IC50 = 2880 nM
   TI
   LI
   LO
   TS
CP0470004
N-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3-(3-oxo-3-piperidin-1-ylpropyl)-3,4-dihydro-1H-1,4-benzodiazepin-8-yl]-2-phenylmethoxyacetamide
   Show/Hide
C34H39N5O6
 1
1
IC50 = 2990 nM
   TI
   LI
   LO
   TS
CP0387248
methyl 3-[(3R)-7-[3-(dimethylamino)phenoxy]-8-[[2-[(4-fluorophenyl)methoxy]acetyl]amino]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31FN4O7
 1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0470005
3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]-N,N-diethylpropanamide
   Show/Hide
C33H39N5O6
 1
1
IC50 = 3410 nM
   TI
   LI
   LO
   TS
CP0405612
methyl 3-[(3R)-7-[4-chloro-3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31ClN4O7
 1
1
IC50 = 3550 nM
   TI
   LI
   LO
   TS
CP0393836
methyl 3-[(3R)-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-7-[2,4,5-trichloro-3-(dimethylamino)phenoxy]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H29Cl3N4O7
 1
1
IC50 = 3780 nM
   TI
   LI
   LO
   TS
CP0412918
N-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-3-(3-oxo-3-pyrrolidin-1-ylpropyl)-3,4-dihydro-1H-1,4-benzodiazepin-8-yl]-2-phenylmethoxyacetamide
   Show/Hide
C33H37N5O6
 1
1
IC50 = 3790 nM
   TI
   LI
   LO
   TS
CP0393769
methyl 3-[(3R)-7-[3-(dimethylamino)phenoxy]-8-[[2-[(3-fluorophenyl)methoxy]acetyl]amino]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31FN4O7
 1
1
IC50 = 4020 nM
   TI
   LI
   LO
   TS
CP0081515
3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]-N-propylpropanamide
   Show/Hide
C32H37N5O6
 1
1
IC50 = 4160 nM
   TI
   LI
   LO
   TS
CP0387225
methyl 3-[(3R)-7-[3-chloro-5-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C30H31ClN4O7
 1
1
IC50 = 5050 nM
   TI
   LI
   LO
   TS
CP0434497
ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate
   Show/Hide
C18H17NO4S
 1
1
IC50 = 6450 nM
   TI
   LI
   LO
   TS
CP0387222
N-cyclopropyl-3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
   Show/Hide
C32H35N5O6
 1
1
IC50 = 7140 nM
   TI
   LI
   LO
   TS
CP0477754
ethyl 1-[(4-methylphenyl)methyl]indole-2-carboxylate
   Show/Hide
C19H19NO2
 1
1
IC50 = 9040 nM
   TI
   LI
   LO
   TS
CP0393771
methyl 3-[(3R)-7-[3-(dimethylamino)phenoxy]-8-[[2-[(4-methoxyphenyl)methoxy]acetyl]amino]-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
   Show/Hide
C31H34N4O8
 1
1
IC50 = 9510 nM
   TI
   LI
   LO
   TS
CP0379409
1-[(4-chlorophenyl)methyl]-2-benzimidazolamine
   Show/Hide
C14H12ClN3
 1
1
IC50 = 11900 nM
   TI
   LI
   LO
   TS
CP0470982
ethyl 1-(4-fluorophenyl)sulfonylindole-2-carboxylate
   Show/Hide
C17H14FNO4S
 1
1
IC50 = 12600 nM
   TI
   LI
   LO
   TS
CP0421302
ethyl 1-(4-nitrophenyl)sulfonylindole-2-carboxylate
   Show/Hide
C17H14N2O6S
 1
1
IC50 = 16900 nM
   TI
   LI
   LO
   TS
CP0559330
ethyl 1-(4-chlorophenyl)sulfonylindole-2-carboxylate
   Show/Hide
C17H14ClNO4S
 1
1
IC50 = 23400 nM
   TI
   LI
   LO
   TS
CP0421301
ethyl 1-(4-methylbenzoyl)indole-2-carboxylate
   Show/Hide
C19H17NO3
 1
1
IC50 = 24600 nM
   TI
   LI
   LO
   TS
CP0470983
1-[(4-chlorophenyl)methyl]-3H-indol-2-imine;hydrochloride
   Show/Hide
C15H14Cl2N2
 1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0142376
(1-tosylbenzimidazol-2-yl)amine
   Show/Hide
C14H13N3O2S
 1
1
IC50 = 54900 nM
   TI
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   TS