General Information of the Compound
Compound ID
CP0393795
Compound Name
N,N-dibutyl-3-[(3R)-7-[3-(dimethylamino)phenoxy]-2,5-dioxo-8-[(2-phenylmethoxyacetyl)amino]-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
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Structure
Formula
C37H47N5O6
Molecular Weight
657.812
Canonical SMILES
CCCCN(CCCC)C(=O)CC[C@H]1NC(=O)c2cc(Oc3cccc(c3)N(C)C)c(NC(=O)COCc3ccccc3)cc2NC1=O
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InChI
InChI=1S/C37H47N5O6/c1-5-7-19-42(20-8-6-2)35(44)18-17-30-37(46)40-31-23-32(38-34(43)25-47-24-26-13-10-9-11-14-26)33(22-29(31)36(45)39-30)48-28-16-12-15-27(21-28)41(3)4/h9-16,21-23,30H,5-8,17-20,24-25H2,1-4H3,(H,38,43)(H,39,45)(H,40,46)/t30-/m1/s1
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InChIKey
BZRLHYRRPVWAPY-SSEXGKCCSA-N
Physicochemical Property
logP
5.9597
Rotatable Bonds
17
Heavy Atom Count
48
Polar Areas
129.31
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137635525
ChEMBL ID
CHEMBL4063525
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03645, Nucleotide-binding oligomerization domain-containing protein 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000870 HEK-Blue Null1-v Homo sapiens (Human)  1
1
IC50 = 1300 nM
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Protein ID: PT03970, Nucleotide-binding oligomerization domain-containing protein 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000870 HEK-Blue Null1-v Homo sapiens (Human)  1
1
IC50 = 1320 nM
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