| Compound ID |
Compound Name |
Compound Formula |
|
CP0417965
|
tert-butyl 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H29FN8O3
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0417964
|
(1-methylcyclopropyl) 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H27FN8O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0428076
|
tert-butyl 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H33N5O3
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0465309
|
propan-2-yl 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H27FN8O3
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0476799
|
tert-butyl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H30N8O3
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0476797
|
tert-butyl 6-[6-[2-fluoro-4-(1,2,4-triazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C26H30FN7O3
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0386166
|
tert-butyl 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H31FN4O5S
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0449241
|
(1-methylcyclopropyl) 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H28N8O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0090790
|
propan-2-yl 4-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate
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|
C21H26FN3O6S
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0386157
|
propan-2-yl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H28N8O3
|
1
|
| 1 |
Ki = 94 nM
|
|
|
|
CP0396609
|
(1-methylcyclopropyl) 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H31N5O3
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0465312
|
tert-butyl 6-[5-methyl-6-[4-(1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C26H31N7O3
|
1
|
| 1 |
Ki = 125 nM
|
|
|
|
CP0440141
|
(1-methylcyclopropyl) 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H29FN4O5S
|
1
|
| 1 |
Ki = 131 nM
|
|
|
|
CP0425700
|
tert-butyl 6-[6-(4-cyano-2-fluorophenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H28FN5O3
|
1
|
| 1 |
Ki = 133 nM
|
|
|
|
CP0460402
|
(1-methylcyclobutyl) 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H31N5O3
|
1
|
| 1 |
Ki = 136 nM
|
|
|
|
CP0449176
|
propan-2-yl 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H29FN4O5S
|
1
|
| 1 |
Ki = 141 nM
|
|
|
|
CP0386162
|
tert-butyl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H31N5O4
|
1
|
| 1 |
Ki = 163 nM
|
|
|
|
CP0417966
|
propan-2-yl 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H31N5O3
|
1
|
| 1 |
Ki = 197 nM
|
|
|
|
CP0460405
|
2-methylpropyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H31N5O3
|
1
|
| 1 |
Ki = 231 nM
|
|
|
|
CP0481439
|
[(2R)-butan-2-yl] 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H31N5O3
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0417963
|
propan-2-yl 6-[5-methyl-6-[4-(triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C25H29N7O3
|
1
|
| 1 |
Ki = 294 nM
|
|
|
|
CP0428078
|
tert-butyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H31N5O3
|
1
|
| 1 |
Ki = 486 nM
|
|
|
|
CP0428080
|
[(2S)-butan-2-yl] 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H31N5O3
|
1
|
| 1 |
Ki = 493 nM
|
|
|
|
CP0465308
|
tert-butyl 6-[6-[2-fluoro-4-(3-methyl-1,2,4-triazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C27H32FN7O3
|
1
|
| 1 |
Ki = 507 nM
|
|
|
|
CP0386164
|
(1-methylcyclopropyl) 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H29N5O3
|
1
|
| 1 |
Ki = 586 nM
|
|
|
|
CP0449177
|
cyclobutyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H29N5O3
|
1
|
| 1 |
Ki = 682 nM
|
|
|
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CP0465310
|
tert-butyl 6-[5-fluoro-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C23H28FN5O3
|
1
|
| 1 |
Ki = 814 nM
|
|
|
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CP0465314
|
propan-2-yl 6-[6-(4-cyano-2-fluorophenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H26FN5O3
|
1
|
| 1 |
Ki = 912 nM
|
|
|
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CP0386159
|
tert-butyl 6-[5-methyl-6-[4-(3-methyl-1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C27H33N7O3
|
1
|
| 1 |
Ki = 948 nM
|
|
|
|
CP0476798
|
propan-2-yl 6-[6-[4-(dimethylcarbamoyl)-2-fluorophenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C26H32FN5O4
|
1
|
| 1 |
Ki = 1148 nM
|
|
|
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CP0476792
|
propan-2-yl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C23H29N5O4
|
1
|
| 1 |
Ki = 1496 nM
|
|
|
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CP0386161
|
ethyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C22H27N5O3
|
1
|
| 1 |
Ki = 1970 nM
|
|
|
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CP0425701
|
propan-2-yl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C23H29N5O3
|
1
|
| 1 |
Ki = 2233 nM
|
|
|
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CP0449184
|
(1-methylcyclopropyl) 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C24H29N5O4
|
1
|
| 1 |
Ki = 3123 nM
|
|
|
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CP0465311
|
(1-methylcyclopropyl) 6-[5-fluoro-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C23H26FN5O3
|
1
|
| 1 |
Ki > 7318 nM
|
|
|
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CP0425702
|
tert-butyl 6-[6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C23H29N5O3
|
1
|
| 1 |
Ki > 8148 nM
|
|
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CP0465313
|
(1-methylcyclopropyl) 6-[6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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|
C23H27N5O3
|
1
|
| 1 |
Ki > 8148 nM
|
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