Brief Information of the Cell Line and Protein
Cell Line ID: CL000398 , A-9
Synonyms
A9
A9 (Hamprecht)
A9(Hamprecht)
AG 9
GM00346
GM-346
GM346
GM00346B
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_3984
Protein ID: PT01310 , Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P11229
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000398  Protein ID: PT01310
 
Compound ID Compound Name Compound Formula
CP0375816
(1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[3.2.1]octane
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C18H19N3S2
 1
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0375500
(1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[3.2.1]octane
   Show/Hide
C18H19N3OS
 1
1
EC50 = 0.5 nM
   TI
   LI
   LO
   TS
CP0405062
(R)-3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[2.2.1]heptane
   Show/Hide
C17H17N3OS
 1
1
EC50 = 0.99 nM
   TI
   LI
   LO
   TS
CP0403809
6-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[3.2.1]octane
   Show/Hide
C12H19N3OS2
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0416658
(1R,5R,6S)-6-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[3.2.1]octane
   Show/Hide
C18H19N3S2
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0376259
1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]-2-[2-(2-{2-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]ethoxy}ethoxy)ethoxy]ethane
   Show/Hide
C24H36N6O5S2
 7
1
EC50 = 7.943 nM
   TI
   LI
   LO
   TS
2
EC50 = 8.5 nM
   TI
   LI
   LO
   TS
3
EC50 = 10 nM
   TI
   LI
   LO
   TS
4
EC50 = 50.12 nM
   TI
   LI
   LO
   TS
5
Ki = 0.1 nM
   TI
   LI
   LO
   TS
6
Ki = 0.12 nM
   TI
   LI
   LO
   TS
7
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0371787
5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid
   Show/Hide
C14H23N3OS
 8
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
EC50 = 57 nM
   TI
   LI
   LO
   TS
3
EC50 = 158.49 nM
   TI
   LI
   LO
   TS
4
EC50 = 200 nM
   TI
   LI
   LO
   TS
5
EC50 = 316.23 nM
   TI
   LI
   LO
   TS
6
Ki = 82 nM
   TI
   LI
   LO
   TS
7
Ki = 158.49 nM
   TI
   LI
   LO
   TS
8
Ki = 3981.07 nM
   TI
   LI
   LO
   TS
CP0403949
3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[2.2.2]octane
   Show/Hide
C18H19N3OS
 1
1
EC50 = 15.7 nM
   TI
   LI
   LO
   TS
CP0500904
3-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane
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C13H21N3OS2
 1
1
EC50 = 22.3 nM
   TI
   LI
   LO
   TS
CP0375675
(1R,5R,6S)-6-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[3.2.1]octane
   Show/Hide
C18H19N3OS
 1
1
EC50 = 28.3 nM
   TI
   LI
   LO
   TS
CP0179471
3-methoxy-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole
   Show/Hide
C19H29N5O6S2
 4
1
EC50 = 63.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 251.19 nM
   TI
   LI
   LO
   TS
3
EC50 = 1995.26 nM
   TI
   LI
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   TS
4
Ki = 50.12 nM
   TI
   LI
   LO
   TS
CP0847519
5-{4-[2-(2-{2-[2-(4-Methoxy-[1,2,5]thiadiazol-3-yloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-[1,2,5]thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydro-pyridine hydrochloride
   Show/Hide
C19H30ClN5O6S2
 2
1
EC50 = 63.1 nM
   TI
   LI
   LO
   TS
2
Ki = 25.12 nM
   TI
   LI
   LO
   TS
CP0441169
3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[2.2.1]heptane
   Show/Hide
C17H17N3OS
 1
1
EC50 = 67.3 nM
   TI
   LI
   LO
   TS
CP0403933
1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-4-aza-tricyclo[2.2.1.0*2,6*]heptane
   Show/Hide
C17H15N3OS
 1
1
EC50 = 70.5 nM
   TI
   LI
   LO
   TS
CP0476699
1,5-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]pentane
   Show/Hide
C21H30N6S4
 2
1
EC50 = 79 nM
   TI
   LI
   LO
   TS
2
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0457009
3-(4-Butoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane
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C13H21N3O2S
 1
1
EC50 = 102 nM
   TI
   LI
   LO
   TS
CP0403635
1-Methyl-5-[4-(3-phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1,2,3,6-tetrahydro-pyridine
   Show/Hide
C17H17N3OS
 1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
CP0441212
1,9-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]nonane
   Show/Hide
C25H38N6S4
 2
1
EC50 = 120 nM
   TI
   LI
   LO
   TS
2
Ki = 17 nM
   TI
   LI
   LO
   TS
CP0409441
3-[(3R,4S)-1-azabicyclo[2.2.1]heptan-3-yl]-4-(3-phenylprop-2-ynoxy)-1,2,5-thiadiazole
   Show/Hide
C17H17N3OS
 1
1
EC50 = 159 nM
   TI
   LI
   LO
   TS
CP0448660
3-(4-Pentyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane
   Show/Hide
C14H23N3O2S
 1
1
EC50 = 164.8 nM
   TI
   LI
   LO
   TS
CP0460763
1,7-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]heptane
   Show/Hide
C23H34N6S4
 2
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
2
Ki = 7.6 nM
   TI
   LI
   LO
   TS
CP0374676
3-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane
   Show/Hide
C15H25N3OS2
 1
1
EC50 = 225 nM
   TI
   LI
   LO
   TS
CP0739672
penta(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether
   Show/Hide
C21H33N5O7S2
 2
1
EC50 = 251.19 nM
   TI
   LI
   LO
   TS
2
Ki = 398.11 nM
   TI
   LI
   LO
   TS
CP0781215
tetra(ethylene glycol)(3-methoxy-1,2,4-thiadiazol-5-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether
   Show/Hide
C19H29N5O6S2
 2
1
EC50 = 251.19 nM
   TI
   LI
   LO
   TS
2
Ki = 199.53 nM
   TI
   LI
   LO
   TS
CP0409501
3-(4-Hexyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane
   Show/Hide
C15H25N3O2S
 1
1
EC50 = 258.9 nM
   TI
   LI
   LO
   TS
CP0460884
1,12-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]dodecane
   Show/Hide
C28H44N6O2S2
 2
1
EC50 = 340 nM
   TI
   LI
   LO
   TS
2
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0406497
1,3-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]propane
   Show/Hide
C19H26N6S4
 2
1
EC50 = 350 nM
   TI
   LI
   LO
   TS
2
Ki = 1.2 nM
   TI
   LI
   LO
   TS
CP0846924
5-{4-[12-(4-Methoxy-[1,2,5]thiadiazol-3-yloxy)-dodecyloxy]-[1,2,5]thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydro-pyridine
   Show/Hide
C23H37N5O3S2
 2
1
EC50 = 398.11 nM
   TI
   LI
   LO
   TS
2
Ki = 1995.26 nM
   TI
   LI
   LO
   TS
CP0395501
3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane
   Show/Hide
C12H19N3OS2
 1
1
EC50 = 430.9 nM
   TI
   LI
   LO
   TS
CP0468061
1,2-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]ethane
   Show/Hide
C18H24N6S4
 2
1
EC50 = 440 nM
   TI
   LI
   LO
   TS
2
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0847851
tri(propylene glycol)(3-methoxy-1,2,4-thiadiazol-5-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether
   Show/Hide
C19H25N5O5S2
 2
1
EC50 = 501.19 nM
   TI
   LI
   LO
   TS
2
Ki = 63.1 nM
   TI
   LI
   LO
   TS
CP0380108
1,4-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]butane
   Show/Hide
C20H28N6S4
 2
1
EC50 = 570 nM
   TI
   LI
   LO
   TS
2
Ki = 0.93 nM
   TI
   LI
   LO
   TS
CP0407175
1,6-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]hexane
   Show/Hide
C22H32N6S4
 2
1
EC50 = 590 nM
   TI
   LI
   LO
   TS
2
Ki = 0.87 nM
   TI
   LI
   LO
   TS
CP0853788
2-[2-(2-{2-[4-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yloxy]-ethoxy}-ethoxy)-ethoxy]-ethanol hydrochloride
   Show/Hide
C16H28ClN3O5S
 2
1
EC50 = 630.96 nM
   TI
   LI
   LO
   TS
2
Ki = 79.43 nM
   TI
   LI
   LO
   TS
CP0399528
1,9-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]nonane
   Show/Hide
C25H38N6O2S2
 2
1
EC50 = 720 nM
   TI
   LI
   LO
   TS
2
Ki = 0.84 nM
   TI
   LI
   LO
   TS
CP0847381
2-(2-(2-(2-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-yloxy)ethoxy)ethoxy)ethoxy)ethanol
   Show/Hide
C16H27N3O5S
 2
1
EC50 = 794.33 nM
   TI
   LI
   LO
   TS
2
Ki = 1000 nM
   TI
   LI
   LO
   TS
CP0847854
tri(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether
   Show/Hide
C17H25N5O5S2
 2
1
EC50 = 794.33 nM
   TI
   LI
   LO
   TS
2
Ki = 316.23 nM
   TI
   LI
   LO
   TS
CP0463033
1,8-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]octane
   Show/Hide
C24H36N6S4
 2
1
EC50 = 920 nM
   TI
   LI
   LO
   TS
2
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0847850
di(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether
   Show/Hide
C15H21N5O4S2
 2
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
2
Ki = 794.33 nM
   TI
   LI
   LO
   TS
CP0449083
1,11-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]undecane
   Show/Hide
C27H42N6S4
 2
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
2
Ki = 0.57 nM
   TI
   LI
   LO
   TS
CP0476680
1,10-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]decane
   Show/Hide
C26H40N6S4
 2
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
2
Ki = 0.32 nM
   TI
   LI
   LO
   TS
CP0849748
Acetic acid 12-[4-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yloxy]-dodecyl ester hydrochloride
   Show/Hide
C22H38ClN3O3S
 2
1
EC50 = 2511.89 nM
   TI
   LI
   LO
   TS
2
Ki = 3.981 nM
   TI
   LI
   LO
   TS
CP0847853
tri(propylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether
   Show/Hide
C19H25N5O5S2
 2
1
EC50 = 3162.28 nM
   TI
   LI
   LO
   TS
2
Ki = 100 nM
   TI
   LI
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   TS
CP0635477
(2-Carbamoyloxy-ethyl)-trimethyl-ammonium chloride
   Show/Hide
C6H15ClN2O2
 7
1
EC50 = 3162.28 nM
   TI
   LI
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   TS
2
EC50 = 3811 nM
   TI
   LI
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   TS
3
EC50 = 5011.87 nM
   TI
   LI
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   TS
4
EC50 = 13000 nM
   TI
   LI
   LO
   TS
5
EC50 = 15848.93 nM
   TI
   LI
   LO
   TS
6
Ki = 3162.28 nM
   TI
   LI
   LO
   TS
7
Ki = 20000 nM
   TI
   LI
   LO
   TS
CP0853783
12-[4-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yloxy]-dodecan-1-ol hydrochloride
   Show/Hide
C20H36ClN3O2S
 2
1
EC50 = 3162.28 nM
   TI
   LI
   LO
   TS
2
Ki = 50.12 nM
   TI
   LI
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   TS
CP0210785
Aceclidine
   Show/Hide
C9H15NO2
 1
1
EC50 = 4466 nM
   TI
   LI
   LO
   TS
CP0449112
3-Butoxy-4-(pyrrolidin-3-yloxy)-[1,2,5]thiadiazole
   Show/Hide
C10H17N3O2S
 1
1
EC50 = 4867 nM
   TI
   LI
   LO
   TS
CP0018455
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide
   Show/Hide
C8H13NO2
 1
1
EC50 = 5603 nM
   TI
   LI
   LO
   TS
CP0445380
3-(Azetidin-3-yloxy)-4-butoxy-[1,2,5]thiadiazole
   Show/Hide
C9H15N3O2S
 1
1
EC50 = 6202 nM
   TI
   LI
   LO
   TS
CP0900174
5-[4-(2-{2-[2-(2-Ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-[1,2,5]thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydro-pyridine hydrochloride
   Show/Hide
C18H32ClN3O5S
 2
1
EC50 = 6309.57 nM
   TI
   LI
   LO
   TS
2
Ki = 398.11 nM
   TI
   LI
   LO
   TS
CP0089021
(+)-pilocarpine
   Show/Hide
C11H16N2O2
 1
1
EC50 = 8792 nM
   TI
   LI
   LO
   TS
CP0383357
1,12-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-ylsulfanyl]dodecane
   Show/Hide
C28H44N6S4
 2
1
EC50 = 13000 nM
   TI
   LI
   LO
   TS
2
Ki = 0.69 nM
   TI
   LI
   LO
   TS
CP0397762
(1R,3S,4R)-3-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[2.2.1]heptane
   Show/Hide
C17H17N3S2
 1
1
EC50 > 100 nM
   TI
   LI
   LO
   TS
CP0382879
1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(3-methoxy-phenyl)-prop-2-ynyl]-oxime
   Show/Hide
C16H18N2O2
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0376490
1,8-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]octane
   Show/Hide
C24H36N6O2S2
 1
1
Ki = 0.19 nM
   TI
   LI
   LO
   TS
CP0471023
1,10-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]decane
   Show/Hide
C26H40N6O2S2
 1
1
Ki = 0.23 nM
   TI
   LI
   LO
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CP0401666
1,6-di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]hexane
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C22H32N6O2S2
 1
1
Ki = 0.61 nM
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CP0377637
1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]-2-{2-[2-(2-{2-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]ethoxy}ethoxy)ethoxy]ethoxy}ethane
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C26H40N6O6S2
 1
1
Ki = 1.5 nM
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CP0511621
1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]-2-(2-{2-[2-(2-{2-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethane
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C28H44N6O7S2
 1
1
Ki = 1.9 nM
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CP0176132
11-[2-[4-[4-(diethylamino)butyl]piperidin-1-yl]acetyl]-5H-benzo[b][1,4]benzodiazepin-6-one
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C28H38N4O2
 1
1
Ki = 3.981 nM
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CP0477109
1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]-2-{2-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]ethoxy}ethane
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C20H28N6O3S2
 1
1
Ki = 4.9 nM
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CP0862620
Acetic acid 2-[2-(2-{2-[4-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yloxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester hydrochloride
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C18H30ClN3O6S
 1
1
Ki = 199.53 nM
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CP0895259
5-(4-{2-[2-(2-Ethoxy-ethoxy)-ethoxy]-ethoxy}-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine hydrochloride
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C16H28ClN3O4S
 1
1
Ki = 630.96 nM
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