Brief Information of the Compound and Protein
Compound Name
1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]-2-[2-(2-{2-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]ethoxy}ethoxy)ethoxy]ethane
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PubChem ID
CID: 9809330
SID: 14886079
Canonical SMILES
CN1CCC=C(C1)c1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1
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Compound Formula C24H36N6O5S2
Compound Structure
Protein Name
Muscarinic acetylcholine receptor M1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Monoamine receptor
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Acetylcholine receptor
Uniprot ID
P11229
Gene Name
CHRM1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000398 A-9 Mus musculus (Mouse)  7
1
EC50 = 7.943 nM
   TI
   LI
   LO
   TS
2
EC50 = 8.5 nM
   TI
   LI
   LO
   TS
3
EC50 = 10 nM
   TI
   LI
   LO
   TS
4
EC50 = 50.12 nM
   TI
   LI
   LO
   TS
5
Ki = 0.1 nM
   TI
   LI
   LO
   TS
6
Ki = 0.12 nM
   TI
   LI
   LO
   TS
7
Ki = 100 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS