Brief Information of the Cell Line and Protein
Cell Line ID: CL000188 , J774A1
Synonyms
J-774A.1
J774.A1
J774 A1
J774A.1
J 774A.1
J774 A.1
Category Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0358
Protein ID: PT03356 , NACHT, LRR and PYD domains-containing protein 3
Gene Name NLRP3
Organism Mus musculus, Mouse
Protein Classification Unclassified protein
Uniprot ID Q8R4B8
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000188  Protein ID: PT03356
 
Compound ID Compound Name Compound Formula
CP0482338
1-(4-tert-butylfuran-2-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea
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C21H26N2O4S
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0060767
1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea
   Show/Hide
C20H24N2O5S
 1
1
IC50 = 21.88 nM
   TI
   LI
   LO
   TS
CP0355213
[(1R)-1-[[(2S)-2-[(2,3-dichlorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
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C21H25BCl2N2O4
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0004620
(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
   Show/Hide
C19H25BN4O4
 1
1
IC50 = 40.74 nM
   TI
   LI
   LO
   TS
CP0543151
[(1R)-1-[[(2S)-2-[(5-chloro-2-fluorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BClFN2O4
 1
1
IC50 = 45.71 nM
   TI
   LI
   LO
   TS
CP0527791
[(1R)-1-[[(2S)-2-[(2,3-difluorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BF2N2O4
 1
1
IC50 = 48.98 nM
   TI
   LI
   LO
   TS
CP0569203
[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyridine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
   Show/Hide
C20H26BN3O4
 1
1
IC50 = 48.98 nM
   TI
   LI
   LO
   TS
CP0544806
[(1R)-1-[[(2S)-2-[(3,6-dichloropyridine-2-carbonyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C20H24BCl2N3O4
 1
1
IC50 = 64.57 nM
   TI
   LI
   LO
   TS
CP0568625
[(1R)-1-[[(2S)-2-[(2,6-dichlorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BCl2N2O4
 1
1
IC50 = 74.13 nM
   TI
   LI
   LO
   TS
CP0527790
[(1R)-1-[[(2S)-2-[(5-chloro-2-methoxybenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C22H28BClN2O5
 1
1
IC50 = 75.86 nM
   TI
   LI
   LO
   TS
CP0567614
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BCl2N2O5
 1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS
CP0355212
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-4-methylpentanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C18H27BCl2N2O4
 1
1
IC50 = 81.28 nM
   TI
   LI
   LO
   TS
CP0569610
[(1R)-1-[[(2S)-2-[(5-fluoro-2-methoxybenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C22H28BFN2O5
 1
1
IC50 = 85.11 nM
   TI
   LI
   LO
   TS
CP0527788
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BCl2N2O4
 1
1
IC50 = 87.1 nM
   TI
   LI
   LO
   TS
CP0572842
[(1R)-1-[[(2S)-2-[(2,5-difluorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BF2N2O4
 1
1
IC50 = 91.2 nM
   TI
   LI
   LO
   TS
CP0535061
Dapansutrile
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C4H7NO2S
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0546921
N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C28H28ClFN2O4S
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0567867
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-1-benzothiophene-3-carboxamide
   Show/Hide
C30H29ClN2O4S2
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0569206
[(1R)-1-[[(2S)-2-[(2,4-difluorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BF2N2O4
 1
1
IC50 = 141.25 nM
   TI
   LI
   LO
   TS
CP0570073
[(1R)-1-[[(2S)-2-[(2,4-dichlorobenzoyl)amino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C21H25BCl2N2O4
 1
1
IC50 = 151.36 nM
   TI
   LI
   LO
   TS
CP0543120
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-(4-prop-2-ynylsulfonylphenyl)ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C27H28ClNO4S2
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0551723
N-(1,3-benzodioxol-4-ylmethyl)-2-(4-fluorophenyl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C27H25FN2O5S
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0578945
[(1R)-3-methyl-1-[[(2S)-2-[(6-methylpyrazine-2-carbonyl)amino]-3-phenylpropanoyl]amino]butyl]boronic acid
   Show/Hide
C20H27BN4O4
 1
1
IC50 = 194.98 nM
   TI
   LI
   LO
   TS
CP0034167
[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C14H19BCl2N2O4
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0574997
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-3-methylbutanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C17H25BCl2N2O4
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0543122
2-(1-benzothiophen-3-yl)-N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C31H31ClN2O4S2
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0579099
N-[(5-chloro-2-prop-2-ynoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C27H25ClN2O4S2
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0579855
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-2-phenylacetyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C20H23BCl2N2O4
 1
1
IC50 = 234.42 nM
   TI
   LI
   LO
   TS
CP0578129
N-[(5-chloro-2-propoxyphenyl)methyl]-2-(4-fluorophenyl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C29H30ClFN2O4S
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0205270
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C27H29ClN2O4S2
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0364715
(1S,2R,4S,7E,11S,12R)-12-[[2-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]ethyl-methylamino]methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
   Show/Hide
C26H33N3O8S
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0551540
N-[(5-chloro-2-nitrophenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C24H22ClN3O5S2
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0577526
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]thiophene-3-carboxamide
   Show/Hide
C26H27ClN2O4S2
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0572371
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[methyl(prop-2-ynyl)sulfamoyl]phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C28H31ClN2O4S2
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0543118
N-(1,3-benzodioxol-4-ylmethyl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C25H24N2O5S2
 1
1
IC50 = 340 nM
   TI
   LI
   LO
   TS
CP0546600
[(1R)-1-[[(2S,3R)-2-[(2,5-dichlorobenzoyl)amino]-3-methylpentanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C18H27BCl2N2O4
 1
1
IC50 = 346.74 nM
   TI
   LI
   LO
   TS
CP0553068
(1S,2R,4S,7E,11S,12R)-12-[[3-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]propyl-methylamino]methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
   Show/Hide
C27H35N3O8S
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0578943
[(1R)-1-[[(2S)-2-[(2,5-dichlorophenyl)sulfonylamino]-3-phenylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C20H25BCl2N2O5S
 1
1
IC50 = 416.87 nM
   TI
   LI
   LO
   TS
CP0411667
5-chloro-2-methoxy-N-[2-[4-[(4-methoxyphenyl)methylsulfamoyl]phenyl]ethyl]benzamide
   Show/Hide
C24H25ClN2O5S
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0572373
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-(4-prop-2-ynylsulfonylphenyl)ethyl]-1-benzothiophene-3-carboxamide
   Show/Hide
C30H28ClNO4S2
 1
1
IC50 = 440 nM
   TI
   LI
   LO
   TS
CP0459762
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-1,2,5-thiadiazole-3-carboxamide
   Show/Hide
C24H25ClN4O4S2
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0579101
N-[[5-chloro-2-(trifluoromethyl)phenyl]methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C25H22ClF3N2O3S2
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0382840
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]furan-3-carboxamide
   Show/Hide
C26H27ClN2O5S
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0473947
N-[(5-chloro-2-pentoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C29H33ClN2O4S2
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0572372
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-(4-morpholin-4-ylsulfonylphenyl)ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C28H33ClN2O5S2
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0567967
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-3-naphthalen-2-ylpropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C25H27BCl2N2O4
 1
1
IC50 = 489.78 nM
   TI
   LI
   LO
   TS
CP0552611
(3R,3aS,9R,9aS,9bS)-3-[[3-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]propyl-methylamino]methyl]-9-hydroxy-6,9-dimethyl-3,3a,4,5,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
   Show/Hide
C27H35N3O8S
 1
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
CP0421381
(3R,3aS,9R,9aS,9bS)-3-[[2-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]ethyl-methylamino]methyl]-9-hydroxy-6,9-dimethyl-3,3a,4,5,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
   Show/Hide
C26H33N3O8S
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0543020
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
   Show/Hide
C30H33ClN2O4S2
 1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0578944
[(1R)-1-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-3-hydroxypropanoyl]amino]-3-methylbutyl]boronic acid
   Show/Hide
C15H21BCl2N2O5
 1
1
IC50 = 512.86 nM
   TI
   LI
   LO
   TS
CP0471811
5-chloro-N-[2-[4-(dibutylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
   Show/Hide
C24H33ClN2O4S
 1
1
IC50 = 550 nM
   TI
   LI
   LO
   TS
CP0550733
N-[(2-butoxy-5-chlorophenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C28H31ClN2O4S2
 1
1
IC50 = 550 nM
   TI
   LI
   LO
   TS
CP0459761
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-1,3-thiazole-4-carboxamide
   Show/Hide
C25H26ClN3O4S2
 1
1
IC50 = 580 nM
   TI
   LI
   LO
   TS
CP0550731
N-[(5-chloro-2-propoxyphenyl)methyl]-3-phenyl-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]propanamide
   Show/Hide
C30H33ClN2O4S
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0572791
N-[(5-chloro-2-propoxyphenyl)methyl]-4-hydroxy-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C28H29ClN2O5S
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0472271
5-chloro-N-[2-[4-[(4-hydroxyphenyl)methylsulfamoyl]phenyl]ethyl]-2-methoxybenzamide
   Show/Hide
C23H23ClN2O5S
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0568566
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(2,2-dimethylpropylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C29H37ClN2O4S2
 1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0459529
N-[(5-fluoro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C27H29FN2O4S2
 1
1
IC50 = 670 nM
   TI
   LI
   LO
   TS
CP0567868
N-[(5-chloro-2-hydroxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C24H23ClN2O4S2
 1
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
CP0550728
N-[(5-chloro-2-methoxyphenyl)methyl]-2-phenyl-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C27H27ClN2O4S
 1
1
IC50 = 690 nM
   TI
   LI
   LO
   TS
CP0472111
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-pyridin-4-ylacetamide
   Show/Hide
C28H30ClN3O4S
 1
1
IC50 = 730 nM
   TI
   LI
   LO
   TS
CP0569062
4-[2-[(5-chloro-2-propoxyphenyl)methyl-(thiophen-3-ylmethyl)amino]ethyl]-N-prop-2-ynylbenzenesulfonamide
   Show/Hide
C26H29ClN2O3S2
 1
1
IC50 = 750 nM
   TI
   LI
   LO
   TS
CP0571372
N-[(5-chloro-2-propoxyphenyl)methyl]-4-nitro-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C28H28ClN3O6S
 1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS
CP0478566
N-[(2-butan-2-yloxy-5-chlorophenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C28H31ClN2O4S2
 1
1
IC50 = 780 nM
   TI
   LI
   LO
   TS
CP0550732
N-[(5-chloro-2-propoxyphenyl)methyl]-2-(1H-indol-3-yl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C31H32ClN3O4S
 1
1
IC50 = 790 nM
   TI
   LI
   LO
   TS
CP0551722
N-[(2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C27H30N2O4S2
 1
1
IC50 = 790 nM
   TI
   LI
   LO
   TS
CP0565338
5-chloro-2-methoxy-N-[2-[4-(2-phenylethylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C24H25ClN2O4S
 1
1
IC50 = 810 nM
   TI
   LI
   LO
   TS
CP0561492
N-[(5-chloro-2-propoxyphenyl)methyl]-2-phenyl-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C29H31ClN2O4S
 1
1
IC50 = 870 nM
   TI
   LI
   LO
   TS
CP0544805
[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(quinoxaline-2-carbonylamino)propanoyl]amino]butyl]boronic acid
   Show/Hide
C23H27BN4O4
 1
1
IC50 = 870.96 nM
   TI
   LI
   LO
   TS
CP0577527
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]pyrazine-2-carboxamide
   Show/Hide
C26H27ClN4O4S
 1
1
IC50 = 880 nM
   TI
   LI
   LO
   TS
CP0563010
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-pyridin-2-ylacetamide
   Show/Hide
C28H30ClN3O4S
 1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
CP0525590
N-[(5-chloro-2-methoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C25H25ClN2O4S2
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0577528
N-[(5-bromo-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C27H29BrN2O4S2
 1
1
IC50 = 910 nM
   TI
   LI
   LO
   TS
CP0166796
3,4-Bis-benzenesulfonyl-furazan 2-oxide
   Show/Hide
C14H10N2O6S2
 1
1
IC50 = 930 nM
   TI
   LI
   LO
   TS
CP0578669
N-(1,3-benzodioxol-4-ylmethyl)-4-fluoro-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C26H23FN2O5S
 1
1
IC50 = 930 nM
   TI
   LI
   LO
   TS
CP0471813
N-[2-[4-(butylsulfamoyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
   Show/Hide
C20H25ClN2O4S
 1
1
IC50 = 970 nM
   TI
   LI
   LO
   TS
CP0467971
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]prop-2-enamide
   Show/Hide
C24H27ClN2O4S
 1
1
IC50 = 970 nM
   TI
   LI
   LO
   TS
CP0478565
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-1H-1,2,4-triazole-5-carboxamide
   Show/Hide
C24H26ClN5O4S
 1
1
IC50 = 1060 nM
   TI
   LI
   LO
   TS
CP0579100
N-[(2-amino-5-chlorophenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C24H24ClN3O3S2
 1
1
IC50 = 1130 nM
   TI
   LI
   LO
   TS
CP0550729
4-[2-[(5-chloro-2-methoxyphenyl)methyl-propylamino]ethyl]-N-prop-2-ynylbenzenesulfonamide
   Show/Hide
C22H27ClN2O3S
 1
1
IC50 = 1150 nM
   TI
   LI
   LO
   TS
CP0579919
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-4-thiophen-3-ylbutanamide
   Show/Hide
C29H33ClN2O4S2
 1
1
IC50 = 1170 nM
   TI
   LI
   LO
   TS
CP0167835
N-[(5-chloro-2-methoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]prop-2-enamide
   Show/Hide
C22H23ClN2O4S
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0569826
N-[4-[(E)-3-(4-hydroxy-3,5-dimethylphenyl)prop-2-enoyl]phenyl]prop-2-enamide
   Show/Hide
C20H19NO3
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0471812
N-[2-[4-(benzylsulfamoyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
   Show/Hide
C23H23ClN2O4S
 1
1
IC50 = 1310 nM
   TI
   LI
   LO
   TS
CP0575875
N-[2-[4-(azetidin-1-ylsulfonyl)phenyl]ethyl]-N-[(5-chloro-2-propoxyphenyl)methyl]-2-(4-fluorophenyl)acetamide
   Show/Hide
C29H32ClFN2O4S
 1
1
IC50 = 1350 nM
   TI
   LI
   LO
   TS
CP0530726
5-chloro-N-[2-[4-(dipropylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
   Show/Hide
C22H29ClN2O4S
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0520757
(1S,2R,4S,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
   Show/Hide
C15H20O3
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0402247
N-[(5-chloro-2-methoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]propanamide
   Show/Hide
C22H25ClN2O4S
 1
1
IC50 = 1470 nM
   TI
   LI
   LO
   TS
CP0550730
N-[(5-chloro-2-propoxyphenyl)methyl]-2-(4-methoxyphenyl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C30H33ClN2O5S
 1
1
IC50 = 1490 nM
   TI
   LI
   LO
   TS
CP0451085
5-chloro-N-[2-[4-[(4-chlorophenyl)methylsulfamoyl]phenyl]ethyl]-2-methoxybenzamide
   Show/Hide
C23H22Cl2N2O4S
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0572699
(E)-3-(3,4-dihydroxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C16H14O3S
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0392328
5-chloro-2-methoxy-N-[2-[4-(propylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C19H23ClN2O4S
 1
1
IC50 = 1640 nM
   TI
   LI
   LO
   TS
CP0451084
N-[2-[4-(azetidin-1-ylsulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
   Show/Hide
C19H21ClN2O4S
 1
1
IC50 = 1660 nM
   TI
   LI
   LO
   TS
CP0561493
N-[(5-chloro-2-propoxyphenyl)methyl]-2-(1H-imidazol-5-yl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]acetamide
   Show/Hide
C26H29ClN4O4S
 1
1
IC50 = 1660 nM
   TI
   LI
   LO
   TS
CP0482339
5-chloro-2-methoxy-N-[4-[4-(methylsulfamoyl)phenyl]butyl]benzamide
   Show/Hide
C19H23ClN2O4S
 1
1
IC50 = 1740 nM
   TI
   LI
   LO
   TS
CP0478564
4-[2-[(5-chloro-2-methoxyphenyl)methyl-prop-2-enylamino]ethyl]-N-prop-2-ynylbenzenesulfonamide
   Show/Hide
C22H25ClN2O3S
 1
1
IC50 = 1780 nM
   TI
   LI
   LO
   TS
CP0472270
5-chloro-2-methoxy-N-[2-[4-[[4-(trifluoromethyl)phenyl]methylsulfamoyl]phenyl]ethyl]benzamide
   Show/Hide
C24H22ClF3N2O4S
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0550727
N-[(5-chloro-2-methoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]hexanamide
   Show/Hide
C25H31ClN2O4S
 1
1
IC50 = 1930 nM
   TI
   LI
   LO
   TS
CP0536294
5-chloro-N-[2-[4-(diethylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
   Show/Hide
C20H25ClN2O4S
 1
1
IC50 = 2010 nM
   TI
   LI
   LO
   TS
CP0446375
5-chloro-2-methoxy-N-[3-[4-(methylsulfamoyl)phenyl]propyl]benzamide
   Show/Hide
C18H21ClN2O4S
 1
1
IC50 = 2030 nM
   TI
   LI
   LO
   TS
CP0552438
5-chloro-2-methoxy-N-[2-[4-(phenylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C22H21ClN2O4S
 1
1
IC50 = 2080 nM
   TI
   LI
   LO
   TS
CP0550312
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C18H18O2S
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0411076
CHEBI:6922
   Show/Hide
C15H20O3
 1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0543119
N-(furan-2-ylmethyl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
   Show/Hide
C22H22N2O4S2
 1
1
IC50 = 2490 nM
   TI
   LI
   LO
   TS
CP0543121
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
   Show/Hide
C34H40BClN2O6S
 1
1
IC50 = 2490 nM
   TI
   LI
   LO
   TS
CP0037451
1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane
   Show/Hide
C10H20N2S4
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0471810
5-chloro-2-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C17H19ClN2O4S
 1
1
IC50 = 3250 nM
   TI
   LI
   LO
   TS
CP0411666
5-chloro-2-methoxy-N-[2-(4-piperazin-1-ylsulfonylphenyl)ethyl]benzamide
   Show/Hide
C20H24ClN3O4S
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0561685
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(propan-2-ylsulfamoylamino)phenyl]prop-2-en-1-one
   Show/Hide
C20H24N2O4S
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0472269
5-chloro-2-methoxy-N-[2-(4-morpholin-4-ylsulfonylphenyl)ethyl]benzamide
   Show/Hide
C20H23ClN2O5S
 1
1
IC50 = 3440 nM
   TI
   LI
   LO
   TS
CP0563564
4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]benzoic acid
   Show/Hide
C17H14O3S
 1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0392327
5-chloro-2-methoxy-N-[2-(4-pyrrolidin-1-ylsulfonylphenyl)ethyl]benzamide
   Show/Hide
C20H23ClN2O4S
 1
1
IC50 = 3530 nM
   TI
   LI
   LO
   TS
CP0570997
(E)-1-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethylphenyl)prop-2-en-1-one
   Show/Hide
C17H15ClO2
 1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0546392
4-fluoro-N-[4-[(E)-3-(4-hydroxy-3,5-dimethylphenyl)prop-2-enoyl]phenyl]benzenesulfonamide
   Show/Hide
C23H20FNO4S
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0536293
5-chloro-2-methoxy-N-[2-(4-piperidin-1-ylsulfonylphenyl)ethyl]benzamide
   Show/Hide
C21H25ClN2O4S
 1
1
IC50 = 5010 nM
   TI
   LI
   LO
   TS
CP0563565
(E)-3-(4-hydroxy-2,5-dimethylphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C18H18O2S
 1
1
IC50 = 5300 nM
   TI
   LI
   LO
   TS
CP0562272
(E)-1-(4-aminophenyl)-3-(4-methoxy-3,5-dimethylphenyl)prop-2-en-1-one
   Show/Hide
C18H19NO2
 1
1
IC50 = 5700 nM
   TI
   LI
   LO
   TS
CP0471815
3-chloro-5-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C17H19ClN2O4S
 1
1
IC50 = 5830 nM
   TI
   LI
   LO
   TS
CP0546918
N-[2-[4-(azetidin-1-ylsulfonyl)phenyl]ethyl]-N-[(5-chloro-2-propoxyphenyl)methyl]-1-benzothiophene-3-carboxamide
   Show/Hide
C30H31ClN2O4S2
 1
1
IC50 = 7580 nM
   TI
   LI
   LO
   TS
CP0476183
5-chloro-N-[2-[4-(hydroxysulfamoyl)phenyl]ethyl]-2-methoxybenzamide
   Show/Hide
C16H17ClN2O5S
 1
1
IC50 = 8400 nM
   TI
   LI
   LO
   TS
CP0568466
(E)-3-(4-hydroxy-3-methylphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C17H16O2S
 1
1
IC50 = 8800 nM
   TI
   LI
   LO
   TS
CP0552252
1-[4-[(E)-3-(4-methoxy-3,5-dimethylphenyl)prop-2-enoyl]phenyl]-3-propylurea
   Show/Hide
C22H26N2O3
 1
1
IC50 = 9600 nM
   TI
   LI
   LO
   TS
CP0562278
(E)-3-(3-chloro-4-hydroxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C16H13ClO2S
 1
1
IC50 = 9700 nM
   TI
   LI
   LO
   TS
CP0570996
(E)-3-(4-hydroxy-3-methoxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C17H16O3S
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0482341
5-chloro-2-hydroxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C16H17ClN2O4S
 1
1
IC50 = 10480 nM
   TI
   LI
   LO
   TS
CP0569690
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-(4-methylsulfinylphenyl)prop-2-en-1-one
   Show/Hide
C18H18O3S
 1
1
IC50 = 10600 nM
   TI
   LI
   LO
   TS
CP0563521
(E)-3-(3-fluoro-4-hydroxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C16H13FO2S
 1
1
IC50 = 10700 nM
   TI
   LI
   LO
   TS
CP0571562
(E)-3-(3,5-diethyl-4-hydroxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C20H22O2S
 1
1
IC50 = 11700 nM
   TI
   LI
   LO
   TS
CP0284486
1-(4-Fluoro-phenyl)-3-(4-hydroxy-3,5-dimethyl-phenyl)-propenone
   Show/Hide
C17H15FO2
 1
1
IC50 = 12300 nM
   TI
   LI
   LO
   TS
CP0562275
(E)-3-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C20H22O3S
 1
1
IC50 = 12700 nM
   TI
   LI
   LO
   TS
CP0563522
(E)-3-(2-fluoro-4-hydroxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C16H13FO2S
 1
1
IC50 = 12700 nM
   TI
   LI
   LO
   TS
CP0571183
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-(4-methylsulfonylphenyl)prop-2-en-1-one
   Show/Hide
C18H18O4S
 1
1
IC50 = 12900 nM
   TI
   LI
   LO
   TS
CP0572668
3-chloro-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C16H17ClN2O3S
 1
1
IC50 = 13360 nM
   TI
   LI
   LO
   TS
CP0569515
(E)-3-(4-hydroxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C16H14O2S
 1
1
IC50 = 14600 nM
   TI
   LI
   LO
   TS
CP0446376
2-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C17H20N2O4S
 1
1
IC50 = 17100 nM
   TI
   LI
   LO
   TS
CP0513341
4-chloro-2-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C17H19ClN2O4S
 1
1
IC50 = 18031 nM
   TI
   LI
   LO
   TS
CP0542770
N-(3-hydroxyphenyl)-2-(1H-indol-6-yl)acetamide
   Show/Hide
C16H14N2O2
 1
1
IC50 = 19620 nM
   TI
   LI
   LO
   TS
CP0562276
(E)-3-[3,5-dimethyl-4-(3-morpholin-4-ylpropoxy)phenyl]-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C25H31NO3S
 1
1
IC50 = 21900 nM
   TI
   LI
   LO
   TS
CP0550311
[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenyl] N-propylcarbamate
   Show/Hide
C22H25NO3S
 1
1
IC50 = 22300 nM
   TI
   LI
   LO
   TS
CP0570989
1-(4-fluorophenyl)-3-[4-[(E)-3-(4-methoxy-3,5-dimethylphenyl)prop-2-enoyl]phenyl]urea
   Show/Hide
C25H23FN2O3
 1
1
IC50 = 23500 nM
   TI
   LI
   LO
   TS
CP0567791
(E)-3-(2,3-dihydro-1-benzofuran-5-yl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C18H16O2S
 1
1
IC50 = 24200 nM
   TI
   LI
   LO
   TS
CP0562273
(E)-1-[4-(dimethylamino)phenyl]-3-(4-methoxy-3,5-dimethylphenyl)prop-2-en-1-one
   Show/Hide
C20H23NO2
 1
1
IC50 = 25900 nM
   TI
   LI
   LO
   TS
CP0563566
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-(4-iodophenyl)prop-2-en-1-one
   Show/Hide
C17H15IO2
 1
1
IC50 = 28600 nM
   TI
   LI
   LO
   TS
CP0544169
5-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]pentanoic acid
   Show/Hide
C23H26O4S
 1
1
IC50 = 28900 nM
   TI
   LI
   LO
   TS
CP0569691
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-(4-phenylphenyl)prop-2-en-1-one
   Show/Hide
C23H20O2
 1
1
IC50 = 29400 nM
   TI
   LI
   LO
   TS
CP0563563
2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]butanoic acid
   Show/Hide
C22H24O4S
 1
1
IC50 = 31700 nM
   TI
   LI
   LO
   TS
CP0472273
3-chloro-2-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C17H19ClN2O4S
 1
1
IC50 = 31780 nM
   TI
   LI
   LO
   TS
CP0472272
3-chloro-4-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
   Show/Hide
C17H19ClN2O4S
 1
1
IC50 = 32750 nM
   TI
   LI
   LO
   TS
CP0571182
1-[4-[(E)-3-(4-methoxy-3,5-dimethylphenyl)prop-2-enoyl]phenyl]-3-propan-2-ylurea
   Show/Hide
C22H26N2O3
 1
1
IC50 = 33200 nM
   TI
   LI
   LO
   TS
CP0571561
1-[4-[(E)-3-(4-methoxy-3,5-dimethylphenyl)prop-2-enoyl]phenyl]-3-(4-methylphenyl)urea
   Show/Hide
C26H26N2O3
 1
1
IC50 = 38700 nM
   TI
   LI
   LO
   TS
CP0076831
Elafibranor
   Show/Hide
C22H24O4S
 1
1
IC50 = 39600 nM
   TI
   LI
   LO
   TS
CP0544171
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(5-methylthiophen-2-yl)phenyl]prop-2-en-1-one
   Show/Hide
C22H20O2S
 1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS
CP0552253
(E)-3-(4-hydroxy-2,6-dimethylphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
   Show/Hide
C18H18O2S
 1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS
CP0561684
2-[[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]methyl]prop-2-enoic acid
   Show/Hide
C22H22O4S
 1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS
CP0562274
2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]acetic acid
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C20H20O4S
 1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS
CP0567792
(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
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C18H18O4S
 1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS
CP0568467
(E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-(4-thiophen-2-ylphenyl)prop-2-en-1-one
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C21H18O2S
 1
1
IC50 > 40000 nM
   TI
   LI
   LO
   TS
CP0482340
2-chloro-6-methoxy-N-[2-[4-(methylsulfamoyl)phenyl]ethyl]benzamide
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C17H19ClN2O4S
 1
1
IC50 = 44420 nM
   TI
   LI
   LO
   TS
CP0562271
(E)-3-(4-methoxy-3,5-dimethylphenyl)-1-(4-methylsulfanylphenyl)prop-2-en-1-one
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C19H20O2S
 1
1
IC50 = 49500 nM
   TI
   LI
   LO
   TS
CP0576877
(2S)-2-[[(2S)-2-[(2,5-dichlorobenzoyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
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C22H24Cl2N2O4
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0576878
[(1R)-1-[(2,5-dichlorobenzoyl)amino]-3-methylbutyl]boronic acid
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C12H16BCl2NO3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0577485
(2S)-4-methyl-2-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]pentanoic acid
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C20H24N4O4
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0578942
[(1R)-1-[[2-[(2,5-dichlorobenzoyl)-methylamino]acetyl]amino]-3-methylbutyl]boronic acid
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C15H21BCl2N2O4
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0579681
[(1R)-1-[[4-[[(2,5-dichlorobenzoyl)amino]methyl]benzoyl]amino]-3-methylbutyl]boronic acid
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C20H23BCl2N2O4
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS