General Information of the Compound
Compound ID
CP0543119
Compound Name
N-(furan-2-ylmethyl)-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide
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Structure
Formula
C22H22N2O4S2
Molecular Weight
442.562
Canonical SMILES
O=C(Cc1ccsc1)N(CCc1ccc(cc1)S(=O)(=O)NCC#C)Cc1ccco1
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InChI
InChI=1S/C22H22N2O4S2/c1-2-11-23-30(26,27)21-7-5-18(6-8-21)9-12-24(16-20-4-3-13-28-20)22(25)15-19-10-14-29-17-19/h1,3-8,10,13-14,17,23H,9,11-12,15-16H2
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InChIKey
AMIGDMNCHIUADJ-UHFFFAOYSA-N
Physicochemical Property
logP
3.0666
Rotatable Bonds
10
Heavy Atom Count
30
Polar Areas
79.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168297087
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03356, NACHT, LRR and PYD domains-containing protein 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000188 J774A1 Mus musculus (Mouse)  1
1
IC50 = 2490 nM
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